Protein: NLGN3
Neuroligin-3 (Gliotactin homolog)

Gene: NLGN3
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9NZ94

Gene Ontology (top 5):
GO:0002087 - regulation of respiratory gaseous exchange by nervous system process
GO:0005886 - plasma membrane
GO:0006898 - receptor-mediated endocytosis
GO:0007158 - neuron cell-cell adhesion
GO:0007268 - chemical synaptic transmission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1322276

NLGNX
Neuroligin-4, X-linked

2

14

High-throughput

0.811

High

1324503

NLGN1
Neuroligin-1

2

14

High-throughput

0.811

High

1339612

NLGN2
Neuroligin-2

2

14

High-throughput

0.811

High

1339600

NLGNY
Neuroligin-4, Y-linked

2

14

High-throughput

0.789

High

658938

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

4

High-throughput

0.691

High

1144521

PSG5
Pregnancy-specific beta-1-glycoprotein 5

1

5

Small-scale

0.656

High

1453098

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

5

Small-scale

0.656

High

946282

NRX1B
Neurexin-1-beta

1

13

Small-scale

0.647

High

1453099

NRX3A
Neurexin-3

1

17

Small-scale

0.647

High

839097

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

1

High-throughput

0.628

High

839181

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

1

High-throughput

0.628

High

61144

T131L
Transmembrane protein 131-like

2

0

High-throughput

0.602

High

65365

TCAF2
TRPM8 channel-associated factor 2

2

0

High-throughput

0.602

High

316086

RECQ4
ATP-dependent DNA helicase Q4

2

0

High-throughput

0.602

High

1289021

NLRX1
NLR family member X1

2

0

High-throughput

0.602

High

543441

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

5

Small-scale

0.587

High

1027930

PSG4
Pregnancy-specific beta-1-glycoprotein 4

1

5

Small-scale

0.587

High

1158743

PSG3
Pregnancy-specific beta-1-glycoprotein 3

1

5

Small-scale

0.587

High

66982

A6NMU8
Neuroligin 4 Y-linked

1

14

High-throughput

0.575

High

1364886

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

2

High-throughput

0.574

High

360485

COX2
Cytochrome c oxidase subunit 2

1

0

Small-scale

0.568

High

996371

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.568

High

637766

FLNA
Filamin-A

1

1

Small-scale

0.560

High

1309808

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

Small-scale

0.549

High

1448371

PICK1
PRKCA-binding protein

1

2

High-throughput

0.541

High

699875

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.536

High

714659

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

2

High-throughput

0.536

High

271185

COBL
Protein cordon-bleu

1

0

High-throughput

0.518

High

728450

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.518

High

927582

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

787462

TGFR1
TGF-beta receptor type-1

1

2

High-throughput

0.515

High

1453095

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.513

High

211955

SPIT1
Kunitz-type protease inhibitor 1

1

3

Small-scale

0.508

High

229582

NRDC
Nardilysin

1

1

Small-scale

0.508

High

388672

C1QA
Complement C1q subcomponent subunit A

1

3

Small-scale

0.508

High

426143

PPB1
Alkaline phosphatase, placental type

1

1

Small-scale

0.508

High

986872

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

3

Small-scale

0.508

High

1226603

MAP1S
Microtubule-associated protein 1S

1

1

Small-scale

0.508

High

1453100

FHOD1
FH1/FH2 domain-containing protein 1

1

1

Small-scale

0.508

High

353779

APCL
Adenomatous polyposis coli protein 2

1

1

High-throughput

0.494

High

586350

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.494

High

732420

PRDX2
Peroxiredoxin-2

1

1

High-throughput

0.494

High

1086453

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

5

High-throughput

0.494

High

1292026

TPRA1
Transmembrane protein adipocyte-associated 1

1

0

Small-scale

0.493

High

323796

AP2A2
AP-2 complex subunit alpha-2

1

0

Small-scale

0.486

High

458715

SAP
Prosaposin

1

0

Small-scale

0.486

High

480913

LEG1
Galectin-1

1

0

Small-scale

0.486

High

1143125

PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1

0

Small-scale

0.486

High

1240632

PLB1
Phospholipase B1, membrane-associated

1

0

Small-scale

0.486

High

1308392

HID1
Protein HID1

1

0

Small-scale

0.486

High

1411805

MIEN1
Migration and invasion enhancer 1

1

0

Small-scale

0.486

High

1420242

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.486

High

1433383

DPEP2
Dipeptidase 2

1

0

Small-scale

0.486

High

1006111

DLG4
Disks large homolog 4

1

19

Small-scale

0.481

High

1152421

DLG2
Disks large homolog 2

1

19

Small-scale

0.481

High

1368725

DLG3
Disks large homolog 3

1

19

Small-scale

0.481

High

1453096

UBQL1
Ubiquilin-1

1

1

High-throughput

0.481

High

212001

EFS
Embryonal Fyn-associated substrate

1

2

Small-scale

0.464

High

654561

FBLN1
Fibulin-1

1

5

Small-scale

0.464

High

1133413

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

1

Small-scale

0.464

High

1162766

KGUA
Guanylate kinase

1

20

Small-scale

0.464

High

1408514

GDF15
Growth/differentiation factor 15

1

1

Small-scale

0.464

High

1417634

EBPL
Emopamil-binding protein-like

1

1

Small-scale

0.464

High

1432720

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.464

High

894212

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.439

High

1340051

OR1FC
Putative olfactory receptor 1F12P

1

0

Small-scale

0.438

High

1232614

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.417

High

1352456

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

2

0

High-throughput

0.328

High

1450251

TM39A
Transmembrane protein 39A

2

0

High-throughput

0.328

High

424115

CP11A
Cholesterol side-chain cleavage enzyme, mitochondrial

1

0

Small-scale

0.299

High

888775

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

0

Small-scale

0.299

High

1144802

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

Small-scale

0.299

High

211439

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.282

High

1061903

TLE5
TLE family member 5

1

0

High-throughput

0.282

High

1340621

TDRD7
Tudor domain-containing protein 7

1

0

High-throughput

0.282

High

185245

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.265

Low

456285

CATD
Cathepsin D

1

0

Small-scale

0.265

Low

617257

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.265

Low

728831

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.265

Low

852119

TNNT3
Troponin T, fast skeletal muscle

1

0

Small-scale

0.265

Low

868268

SYQ
Glutamine--tRNA ligase

1

0

Small-scale

0.265

Low

903814

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.265

Low

929331

OAZ1
Ornithine decarboxylase antizyme 1

1

0

Small-scale

0.265

Low

1254148

CA122
Uncharacterized protein C1orf122

1

0

Small-scale

0.265

Low

1323173

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.265

Low

1401180

SPAG5
Sperm-associated antigen 5

1

0

Small-scale

0.265

Low

1420529

IPKB
cAMP-dependent protein kinase inhibitor beta

1

0

Small-scale

0.265

Low

1449565

MA2C1
Alpha-mannosidase 2C1

1

0

Small-scale

0.265

Low

1453097

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.265

Low

516296

CGB3
Choriogonadotropin subunit beta 3

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025