HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: ZCRB1 (Q8TBF4)
Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)
Gene: ZCRB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 29802200
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 217
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (3-181): 3.06e-45: 160: 18.65
+	Hs
		1083184 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		ZCRB1_HUMAN (1-217): 1.57e-56: 180: 100.00
+	Hs
		516635 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP5_HUMAN (1-179): 2.36e-39: 140: 15.54
+	At
		1247086 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		Q8RWF8_ARATH (7-167): 1.58e-32: 121: 20.86
+	Hs
		442193 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (11-196): 1.86e-23: 99.6: 12.37
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (11-99): 1.42e-22: 96.9: 19.10
+	Hs
		441901 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CSTF2_HUMAN (10-132): 3.67e-31: 121: 23.39
+	Hs
		442150 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CIRBP_HUMAN (5-86): 4.16e-30: 111: 32.93
+	Hs
		516471 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TIAR_HUMAN (3-142): 1.74e-18: 84.3: 14.89
+	Hs
		516674 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		RBM4_HUMAN (11-103): 1.52e-18: 84.2: 21.51
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (3-125): 7.02e-18: 82.7: 17.89
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (11-196): 1.86e-23: 99.6: 12.37
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (11-99): 1.42e-22: 96.9: 19.10
+	Hs
		442070 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RBM3_HUMAN (5-91): 1.58e-24: 96.3: 29.89
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (3-125): 7.02e-18: 82.7: 17.89
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (3-125): 1.72e-18: 84.3: 18.70
+	Hs
		442076 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIAR_HUMAN (3-142): 1.74e-18: 84.3: 14.89
+	Hs
		442178 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SF3B4_HUMAN (101-215): 5.02e-12: 66.1: 9.84