HitPredict

Interactor 1: FCG3A (P08637)
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene: FCGR3A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	8189062
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019722 - calcium-mediated signaling GO:0032760 - positive regulation of tumor necrosis factor production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 254 Hs			1 635
+	Mm
		722897 CD22_MOUSE (15-252): 4.57e-32: 125: 15.55		KSYK_MOUSE (1-635): 0: 567: 92.13
+	Hs
		796632 FCRL3_HUMAN (10-192): 1.43e-24: 103: 18.00		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519328 FCGR1_HUMAN (27-234): 3.56e-22: 95.8: 15.39		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519406 FCERA_HUMAN (102-248): 1.33e-16: 78.5: 16.46		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519372 FCG2A_HUMAN (109-248): 5.3e-13: 69.2: 18.67		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		796482 FCRL3_HUMAN (10-192): 1.43e-24: 103: 18.00		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		523211 TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		793638 DCC_HUMAN (27-221): 6.83e-36: 137: 18.14		FAK1_HUMAN (344-626): 1.88e-57: 211: 39.30
+	Hs
		433507 TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Dm
		219802 O44924_DROME (12-211): 9.95e-33: 127: 14.72		ABL_DROME (4-374): 5.52e-57: 210: 14.54
+	Hs
		442771 FCGR1_HUMAN (27-234): 3.56e-22: 95.8: 15.39		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		519400 FCERA_HUMAN (102-248): 1.33e-16: 78.5: 16.46		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		522812 FCG2C_HUMAN (98-248): 1.33e-13: 71.2: 17.68		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		338300 CNTN2_HUMAN (12-188): 1.01e-23: 101: 14.85		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		522811 FCG2B_HUMAN (98-248): 1.7e-13: 70.8: 17.68		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		411560 FCG3A_HUMAN (109-249): 1.14e-12: 67.7: 15.89		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		412048 FCG2C_HUMAN (98-248): 1.33e-13: 71.2: 17.68		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		412047 FCG2B_HUMAN (98-248): 1.7e-13: 70.8: 17.68		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		789014 TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Mm
		435878 FCGR1_MOUSE (15-241): 1.04e-20: 92: 15.48		HCK_MOUSE (15-176): 1.32e-38: 151: 23.37