HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016477 - cell migration GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 1363
+	Hs
		443165 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		VGFR1_HUMAN (19-1355): 0: 821: 37.61
+	Hs
		443234 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		FLT3_HUMAN (837-1217): 1.41e-97: 338: 45.98
+	Hs
		650056 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		FGFR3_HUMAN (39-230): 6.05e-26: 117: 12.98
+	Hs
		443179 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		FGFR4_HUMAN (2-238): 3.8e-26: 118: 13.21
+	Hs
		443180 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		FGFR3_HUMAN (39-230): 6.05e-26: 117: 12.98
+	Hs
		541347 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		FGFR1_HUMAN (2-160): 3.16e-15: 83.1: 11.31
+	Hs
		443143 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		FGFR1_HUMAN (2-160): 3.16e-15: 83.1: 11.31
+	Hs
		541439 CDK16_HUMAN (1-297): 6.41e-124: 364: 51.68		FGFR1_HUMAN (2-160): 3.16e-15: 83.1: 11.31