HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: WDR74 (Q6RFH5)
WD repeat-containing protein 74 (NOP seven-associated protein 1)
Gene: WDR74

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0042273 - ribosomal large subunit biogenesis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 385
+	Hs
		447594 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		FBW1A_HUMAN (24-374): 1.55e-71: 236: 14.72
+	Hs
		447501 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		NLE1_HUMAN (128-383): 1.24e-51: 181: 15.02
+	Hs
		447301 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		SNR40_HUMAN (2-253): 7.03e-50: 173: 12.06
+	Mm
		1223419 NPM_MOUSE (1-294): 9.29e-141: 400: 93.54		FBXW7_MOUSE (2-206): 2.51e-33: 133: 11.22
+	Hs
		447284 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Hs
		446838 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98
+	Hs
		288678 NPM3_HUMAN (10-119): 6.16e-58: 185: 43.75		WDR74_HUMAN (1-385): 4.56e-94: 288: 100.00
+	Hs
		288793 NPM3_HUMAN (10-119): 6.16e-58: 185: 43.75		NLE1_HUMAN (128-383): 1.24e-51: 181: 15.02