HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11748221
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 197
+	Hs
		449690 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		927926 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Hs
		980642 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		925827 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		817954 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980859 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		881797 SOX10_HUMAN (4-98): 1.86e-21: 93.2: 14.74		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817955 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		178916 TOX3_HUMAN (91-165): 4.65e-29: 115: 40.00		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980649 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		567682 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817967 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980847 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		993604 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Dm
		558375 DICH_DROME (7-101): 3.34e-27: 108: 24.21		GROU_DROME (2-163): 3.54e-59: 198: 54.44