HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30773093, 30979931
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005856 - cytoskeleton GO:0008092 - cytoskeletal protein binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 763
+	Hs
		621610 LAMA2_HUMAN (2-265): 1.15e-49: 178: 21.19		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		433146 LAMB1_HUMAN (1-248): 3.31e-37: 141: 23.44		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		434379 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		932000 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		213885 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64
+	Hs
		213882 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64
+	Hs
		451193 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		418881 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		213883 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64
+	Hs
		434349 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		434344 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		213894 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64
+	Hs
		681779 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		110795 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		625341 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85