HitPredict

Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Interactor 2: NECD (Q99608)
Necdin
Gene: NDN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26871637, 24722188, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 321
+	Mm
		470766 NFL_MOUSE (1-543): 1.19e-147: 436: 93.93		NECD_MOUSE (1-321): 3.34e-119: 347: 82.15
+	Hs
		1127825 KRT81_HUMAN (12-402): 8.82e-86: 276: 30.10		NECD_HUMAN (1-321): 1.69e-122: 355: 100.00
+	Hs
		474922 VIME_HUMAN (34-402): 6.77e-84: 270: 49.59		NECD_HUMAN (1-321): 1.69e-122: 355: 100.00
+	Hs
		566439 K2C5_HUMAN (55-403): 3.07e-59: 208: 31.53		NECD_HUMAN (1-321): 1.69e-122: 355: 100.00
+	Hs
		407334 K2C6B_HUMAN (55-419): 2.72e-59: 207: 30.71		NECD_HUMAN (1-321): 1.69e-122: 355: 100.00
+	Hs
		474848 VIME_HUMAN (34-402): 6.77e-84: 270: 49.59		MAGE2_HUMAN (59-310): 1.21e-64: 214: 28.18
+	Hs
		116876 I6L9F6_HUMAN (219-376): 2.51e-29: 119: 61.01		NECD_HUMAN (1-321): 1.69e-122: 355: 100.00