HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: G3BP1 (Q13283)
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
Gene: G3BP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25324306, 22446626
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 466
+	Hs
		1030413 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		852040 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		1030438 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		453703 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		1020248 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		453376 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SAFB1_HUMAN (93-439): 7.61e-35: 140: 12.39
+	Sc
		376881 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		BRE5_YEAST (9-441): 5.6e-45: 166: 15.31
+	Dm
		1249158 Q9VBQ1_DROME (98-189): 1.58e-23: 104: 30.44		Q8SYC0_DROME (23-421): 1.53e-51: 180: 12.69
+	Hs
		201689 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		CELF5_HUMAN (200-456): 2.14e-15: 80.1: 10.86
+	Hs
		311334 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CELF2_HUMAN (318-402): 4.48e-12: 70: 17.78
+	Hs
		453511 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		201697 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Mm
		825794 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		SRSF9_MOUSE (342-454): 5.28e-14: 73.1: 30.97
+	Hs
		1272074 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		162101 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		609979 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		852118 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Dm
		822822 RB97D_DROME (9-181): 5.67e-47: 167: 49.13		RB27C_DROME (319-464): 1.03e-12: 71.6: 22.15
+	Hs
		1272085 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Dm
		1213098 Q8IMS8_DROME (98-189): 7.59e-24: 104: 30.44		Q8IP90_DROME (331-422): 7.57e-15: 79.3: 19.39