HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: XRN1 (Q8IZH2)
5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)
Gene: XRN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231747
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane GO:0032211 - negative regulation of telomere maintenance via telomerase
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 1706
+	Hs
		609954 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		XRN1_HUMAN (1-1706): 0: 2785: 100.00
+	Hs
		1031389 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		XRN1_HUMAN (1-1706): 0: 2785: 100.00
+	Sc
		376636 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		XRN1_YEAST (1-1267): 0: 1403: 32.34
+	Hs
		453602 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		XRN2_HUMAN (1-700): 0: 978: 34.46
+	Hs
		610043 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		XRN2_HUMAN (1-700): 0: 978: 34.46
+	Hs
		852164 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		XRN2_HUMAN (1-700): 0: 978: 34.46
+	Hs
		1306010 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		XRN2_HUMAN (1-700): 0: 978: 34.46
+	Sc
		376906 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		XRN2_YEAST (349-719): 4.07e-110: 377: 24.55