Protein: CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)

Gene: CPSM, CPS1
Organism: Homo sapiens
Interactions: 134
UniProt ID: P31327

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0004087 - carbamoyl-phosphate synthase (ammonia) activity
GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004175 - endopeptidase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275249

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

3

2

High-throughput

0.662

High

725621

KIRR2
Kin of IRRE-like protein 2

3

0

High-throughput

0.638

High

349654

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

1

High-throughput

0.628

High

681759

RBTN2
Rhombotin-2

2

3

High-throughput

0.628

High

725595

YBEY
Endoribonuclease YbeY

2

3

High-throughput

0.628

High

725615

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

3

High-throughput

0.628

High

725636

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

1

High-throughput

0.628

High

725650

TMM70
Transmembrane protein 70, mitochondrial

2

1

High-throughput

0.628

High

725613

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

3

High-throughput

0.611

High

725679

AGO2
Protein argonaute-2

2

2

High-throughput

0.611

High

725637

ARHGQ
Rho guanine nucleotide exchange factor 26

3

3

High-throughput

0.609

High

260838

RAMP3
Receptor activity-modifying protein 3

2

0

High-throughput

0.576

High

725597

1433Z
14-3-3 protein zeta/delta

2

7

High-throughput

0.571

High

725640

AURKB
Aurora kinase B

2

4

High-throughput

0.571

High

725642

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.554

High

216634

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.536

High

219923

XRCC3
DNA repair protein XRCC3

1

4

High-throughput

0.536

High

288226

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

3

High-throughput

0.536

High

289756

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

1

High-throughput

0.536

High

361608

OTC
Ornithine transcarbamylase, mitochondrial

1

4

High-throughput

0.536

High

534692

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.536

High

655712

TBG1
Tubulin gamma-1 chain

1

9

High-throughput

0.536

High

682008

RBTN1
Rhombotin-1

1

2

High-throughput

0.536

High

690462

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

725588

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.536

High

725591

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

725600

FOXF1
Forkhead box protein F1

1

1

High-throughput

0.536

High

725602

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

2

High-throughput

0.536

High

725610

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.536

High

725617

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.536

High

725619

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

2

High-throughput

0.536

High

725634

TRI43
Tripartite motif-containing protein 43

1

3

High-throughput

0.536

High

725638

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

3

High-throughput

0.536

High

725639

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.536

High

725641

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

725643

DNJC7
DnaJ homolog subfamily C member 7

1

7

High-throughput

0.536

High

725645

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.536

High

725646

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

2

High-throughput

0.536

High

725648

NPS3B
Protein NipSnap homolog 3B

1

5

High-throughput

0.536

High

725649

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

725652

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

1

High-throughput

0.536

High

725653

LDH6B
L-lactate dehydrogenase A-like 6B

1

3

High-throughput

0.536

High

725656

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.536

High

725672

DIC
Mitochondrial dicarboxylate carrier

1

3

High-throughput

0.536

High

725673

NPS3A
Protein NipSnap homolog 3A

1

5

High-throughput

0.536

High

725676

MRM2
rRNA methyltransferase 2, mitochondrial

1

2

High-throughput

0.536

High

725682

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

3

High-throughput

0.536

High

725684

RT02
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.536

High

725598

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.513

High

725623

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.513

High

725660

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

725681

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.513

High

521216

ARAF
Serine/threonine-protein kinase A-Raf

1

5

Small-scale

0.508

High

591497

H2AX
Histone H2AX

1

2

High-throughput

0.489

High

725594

AP1S2
AP-1 complex subunit sigma-2

1

1

High-throughput

0.489

High

725616

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.489

High

725626

FA83F
Protein FAM83F

1

1

High-throughput

0.489

High

725627

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

725659

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.489

High

725667

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.489

High

725644

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

4

Small-scale

0.481

High

156998

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

193215

SOCS1
Suppressor of cytokine signaling 1

1

6

Small-scale

0.479

High

330690

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

407398

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

420389

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

461187

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

468108

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

507579

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

651178

CBL
E3 ubiquitin-protein ligase CBL

1

7

High-throughput

0.479

High

656049

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.479

High

690764

1433T
14-3-3 protein theta

1

7

High-throughput

0.479

High

725586

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

725587

IF4A3
Eukaryotic initiation factor 4A-III

1

6

High-throughput

0.479

High

725589

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

725590

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

725592

TSP3
Thrombospondin-3

1

2

High-throughput

0.479

High

725596

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

725599

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

725601

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

725603

CUL3
Cullin-3

1

4

High-throughput

0.479

High

725605

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

725608

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

725620

RICTR
Rapamycin-insensitive companion of mTOR

1

2

Small-scale

0.479

High

725622

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

725624

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

725629

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

725630

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.479

High

725631

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

Small-scale

0.479

High

725632

HDAC2
Histone deacetylase 2

1

14

High-throughput

0.479

High

725635

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

725647

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

725655

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

725657

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

725658

ECT2
Protein ECT2

1

9

High-throughput

0.479

High

725662

ANM8
Protein arginine N-methyltransferase 8

1

2

Small-scale

0.479

High

725663

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

725664

SALL1
Sal-like protein 1

1

1

High-throughput

0.479

High

725666

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

725669

RM27
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.479

High

725671

HDAC6
Protein deacetylase HDAC6

1

13

High-throughput

0.479

High

725674

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

725675

TES
Testin

1

2

High-throughput

0.479

High

725678

FBXL4
F-box/LRR-repeat protein 4

1

1

Small-scale

0.479

High

222754

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

297157

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.458

High

332785

KCNK5
Potassium channel subfamily K member 5

1

0

High-throughput

0.458

High

389967

ALBU
Albumin

1

0

Small-scale

0.458

High

725625

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

725628

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

725668

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.458

High

400365

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

Small-scale

0.457

High

725604

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

725609

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.445

High

725611

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

725651

TR61B
tRNA

1

1

High-throughput

0.445

High

725670

UXT
Protein UXT

1

1

Small-scale

0.445

High

238405

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.437

High

725606

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.437

High

725607

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.437

High

725614

VIR
Protein virilizer homolog

1

2

High-throughput

0.437

High

725654

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.437

High

725661

ANLN
Anillin

1

3

High-throughput

0.437

High

725680

TRI33
E3 ubiquitin-protein ligase TRIM33

1

17

High-throughput

0.437

High

725683

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

725685

ASB1
Ankyrin repeat and SOCS box protein 1

1

1

High-throughput

0.437

High

725633

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.426

High

725665

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.426

High

725612

DB121
Beta-defensin 121

2

0

High-throughput

0.328

High

725677

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

587013

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

725593

FOXG1
Forkhead box protein G1

1

0

High-throughput

0.279

Low

725618

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

725686

SNX5
Sorting nexin-5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025