HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: XRN2 (Q9H0D6)
5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)
Gene: XRN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 22446626
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 950
+	Hs
		610043 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		XRN2_HUMAN (1-950): 0: 1552: 100.00
+	Hs
		852164 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		XRN2_HUMAN (1-950): 0: 1552: 100.00
+	Hs
		1306010 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		XRN2_HUMAN (1-950): 0: 1552: 100.00
+	Hs
		453472 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		XRN1_HUMAN (1-685): 0: 848: 38.70
+	Hs
		609954 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		XRN1_HUMAN (1-685): 0: 848: 38.70
+	Sc
		376636 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		XRN1_YEAST (1-702): 0: 792: 34.21
+	Hs
		1031389 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		XRN1_HUMAN (1-685): 0: 848: 38.70
+	Sc
		376906 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		XRN2_YEAST (405-884): 5.45e-95: 324: 30.39