HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30209976
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 1191
+	Hs
		201713 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		162161 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		610054 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1329984 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1306023 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1048234 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1288220 MSI2H_HUMAN (2-91): 6.69e-16: 79.8: 35.56		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		453413 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		201679 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		162068 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		609908 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		852082 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136287 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136248 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1048096 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136221 MSI2H_HUMAN (2-91): 6.69e-16: 79.8: 35.56		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1031360 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1056955 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21
+	Zm
		10866 A0A1D6F8R0_MAIZE (7-362): 2.55e-18: 87.9: 21.91		C0P861_MAIZE (514-895): 4.14e-17: 89.2: 9.33
+	Dm
		375648 RB87F_DROME (93-189): 1.58e-20: 93.7: 26.80		RPB1_DROME (644-998): 4.65e-09: 63.1: 10.28