Protein: ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic (EC 1.2.1.-) (EC 1.2.1.4) (Mg(2+)-activated acetaldehyde dehydrogenase) (Mg(2+)-ACDH)

Gene: ALDH6, ALD6
Organism: Saccharomyces cerevisiae S288C
Interactions: 180
UniProt ID: P54115

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006068 - ethanol catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850138

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

5

High-throughput

0.640

High

727236

HS104
Heat shock protein 104

3

3

Small-scale

0.633

High

527407

HSP72
Heat shock protein SSA2

3

9

High-throughput

0.624

High

825466

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

3

High-throughput

0.611

High

671000

SIS1
Protein SIS1

2

4

High-throughput

0.601

High

368729

PMG1
Phosphoglycerate mutase 1

2

0

High-throughput

0.585

High

926267

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

14

Small-scale

0.575

High

524819

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.571

High

545877

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.571

High

676246

MAS5
Mitochondrial protein import protein MAS5

2

1

High-throughput

0.571

High

792693

SSDH
Succinate-semialdehyde dehydrogenase [NADP(+)]

1

14

High-throughput

0.553

High

394803

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.536

High

531378

METK1
S-adenosylmethionine synthase 1

1

2

High-throughput

0.536

High

701556

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.536

High

734175

EF2
Elongation factor 2

1

1

High-throughput

0.536

High

926269

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

558825

CAF20
Cap-associated protein CAF20

2

2

High-throughput

0.533

High

737920

HOG1
Mitogen-activated protein kinase HOG1

2

2

High-throughput

0.533

High

518360

IF4A
ATP-dependent RNA helicase eIF4A

2

1

High-throughput

0.521

High

740688

CBS
Cystathionine beta-synthase

1

3

High-throughput

0.515

High

815941

PP2C2
Protein phosphatase 2C homolog 2

1

0

High-throughput

0.513

High

923095

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

926291

NEW1
[NU+] prion formation protein 1

1

0

High-throughput

0.513

High

376331

YPT1
GTP-binding protein YPT1

1

1

High-throughput

0.500

High

656582

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.500

High

814250

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.500

High

822964

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.500

High

918102

RPN14
26S proteasome regulatory subunit RPN14

1

4

High-throughput

0.500

High

926298

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.500

High

709443

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.480

High

737108

CDC11
Cell division control protein 11

1

0

High-throughput

0.479

High

797825

CS111
F-box protein COS111

1

0

High-throughput

0.479

High

797979

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

806641

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.479

High

823209

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

825039

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.479

High

922170

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.479

High

926271

IMA1
Importin subunit alpha

1

0

High-throughput

0.479

High

926274

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.479

High

393157

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

410274

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

433783

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

435277

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

439398

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

442054

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

448775

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

454754

KAPR
cAMP-dependent protein kinase regulatory subunit

1

2

Small-scale

0.479

High

470002

FUMH
Fumarate hydratase, mitochondrial

1

2

High-throughput

0.479

High

504356

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

554721

YPK1
Serine/threonine-protein kinase YPK1

1

1

High-throughput

0.479

High

579878

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

618917

ARF2
ADP-ribosylation factor 2

1

1

High-throughput

0.479

High

621394

METK2
S-adenosylmethionine synthase 2

1

2

High-throughput

0.479

High

645497

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.479

High

645765

HSP74
Heat shock protein SSA4

1

9

High-throughput

0.479

High

679951

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

747988

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

785951

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.479

High

795484

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

802317

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

812555

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

823441

MPM1
Mitochondrial peculiar membrane protein 1

1

1

High-throughput

0.479

High

918642

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

921468

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

925362

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

368029

ENO2
Enolase 2

1

0

High-throughput

0.458

High

368473

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

383836

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

416468

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

436102

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

503179

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

555126

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

674768

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689598

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

702312

MGLL
Monoglyceride lipase

1

0

High-throughput

0.458

High

747517

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

753520

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

778475

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

796886

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

806788

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

825808

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

828307

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

866286

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

926270

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

926283

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

926289

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

926296

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

459138

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.457

High

625036

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.457

High

632394

CG11
G1/S-specific cyclin CLN1

1

4

High-throughput

0.457

High

633499

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.457

High

688759

RFA2
Replication factor A protein 2

1

3

High-throughput

0.457

High

724887

RAD16
DNA repair protein RAD16

1

1

High-throughput

0.457

High

744210

RAD24
Checkpoint protein RAD24

1

3

High-throughput

0.457

High

746349

RAD54
DNA repair and recombination protein RAD54

1

4

High-throughput

0.457

High

813954

RBG1
Ribosome-interacting GTPase 1

1

3

High-throughput

0.457

High

816143

HAT2
Histone acetyltransferase type B subunit 2

1

6

High-throughput

0.457

High

823137

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.457

High

823190

RAD26
DNA repair and recombination protein RAD26

1

4

High-throughput

0.457

High

836078

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.457

High

919397

RBG2
Ribosome-interacting GTPase 2

1

3

High-throughput

0.457

High

926268

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.457

High

926280

UTP5
U3 small nucleolar RNA-associated protein 5

1

2

High-throughput

0.457

High

926281

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.457

High

926282

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

926286

RBX1
RING-box protein HRT1

1

1

High-throughput

0.457

High

926293

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.457

High

453736

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

742159

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

819481

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

824517

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

826466

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.445

High

677047

GID7
GID complex subunit 7

1

2

High-throughput

0.437

High

707881

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

750749

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.437

High

752981

IXR1
Intrastrand cross-link recognition protein

1

2

Small-scale

0.437

High

803642

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

812099

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.437

High

865698

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

916943

VID30
GID complex subunit 1

1

1

High-throughput

0.437

High

917043

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.437

High

918142

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

922639

HST2
NAD-dependent protein deacetylase HST2

1

7

High-throughput

0.437

High

926277

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.437

High

926285

SUB2
ATP-dependent RNA helicase SUB2

1

2

High-throughput

0.437

High

926290

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

926292

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.437

High

926295

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

926297

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.437

High

631980

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.426

High

386820

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

486505

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.407

High

836838

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.407

High

863685

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

863985

JJJ2
J protein JJJ2

1

2

High-throughput

0.407

High

926275

CLU
Clustered mitochondria protein 1

1

3

High-throughput

0.407

High

926276

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.407

High

688812

RFA3
Replication factor A protein 3

2

0

High-throughput

0.310

High

826046

ULP2
Ubiquitin-like-specific protease 2

2

0

Small-scale

0.306

High

575495

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

602136

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.279

Low

782406

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

825379

FYV10
GID complex subunit 9

1

0

High-throughput

0.269

Low

518102

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

448398

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

644669

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.261

Low

702269

YJU2
Splicing factor YJU2

1

0

High-throughput

0.261

Low

743264

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.261

Low

795733

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.261

Low

802889

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.261

Low

843217

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

865474

BFA1
Mitotic check point protein BFA1

1

0

High-throughput

0.261

Low

917771

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

926278

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.261

Low

926288

DIA2
Protein DIA2

1

0

High-throughput

0.261

Low

926294

WTM1
Transcriptional modulator WTM1

1

0

High-throughput

0.261

Low

610185

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

661550

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

676663

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

701729

URA7
CTP synthase 1

1

0

High-throughput

0.249

Low

738897

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

796139

POA1
ADP-ribose 1''-phosphate phosphatase

1

0

High-throughput

0.249

Low

798694

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

800813

RCK2
Serine/threonine-protein kinase RCK2

1

0

High-throughput

0.249

Low

803092

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

805380

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.249

Low

826732

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

834719

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.249

Low

865033

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.249

Low

868435

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.249

Low

893394

LGUL
Glyoxalase I

1

0

High-throughput

0.249

Low

924676

NRK1
Nicotinamide riboside kinase

1

0

High-throughput

0.249

Low

926272

COFI
Cofilin

1

0

High-throughput

0.249

Low

926273

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

926279

YD391
Uncharacterized protein YDR391C

1

0

High-throughput

0.249

Low

926284

YL352
F-box protein YLR352W

1

0

High-throughput

0.249

Low

926287

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

427397

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

810740

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025