HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: HDGR2 (Q7Z4V5)
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
Gene: HDGFL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006281 - DNA repair GO:1905168 - positive regulation of double-strand break repair via homologous recombination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 671
+	Hs
		455763 PARP1_HUMAN (1-1014): 0: 1362: 100.00		NSD1_HUMAN (2-668): 2.86e-90: 310: 12.29
+	Hs
		331702 PARP1_HUMAN (1-1014): 0: 1362: 100.00		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		455840 PARP1_HUMAN (1-1014): 0: 1362: 100.00		NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66
+	Hs
		265946 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PSIP1_HUMAN (1-553): 1.35e-54: 197: 23.49
+	Hs
		455247 PARP1_HUMAN (1-1014): 0: 1362: 100.00		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		455508 PARP1_HUMAN (1-1014): 0: 1362: 100.00		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		455242 PARP1_HUMAN (1-1014): 0: 1362: 100.00		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78
+	Hs
		456024 PARP1_HUMAN (1-1014): 0: 1362: 100.00		HDGR3_HUMAN (2-194): 5.06e-22: 96.6: 43.43
+	Hs
		455559 PARP1_HUMAN (1-1014): 0: 1362: 100.00		NIPBL_HUMAN (100-662): 1.42e-17: 89.7: 16.10
+	Hs
		1190739 PARP2_HUMAN (514-1014): 0: 594: 41.72		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		855575 PARP2_HUMAN (514-1014): 0: 594: 41.72		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		102360 G3V167_HUMAN (514-964): 3.03e-178: 530: 41.09		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		1188726 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NSD1_HUMAN (2-668): 2.86e-90: 310: 12.29
+	Hs
		331836 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		1188822 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66
+	Hs
		266030 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		PSIP1_HUMAN (1-553): 1.35e-54: 197: 23.49
+	Hs
		855501 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		1189033 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		1115538 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		1154043 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NIPBL_HUMAN (100-662): 1.42e-17: 89.7: 16.10