Protein: Q8SY39
ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (DEAD box protein 54)

Gene: Q8SY39, CG6994
Organism: Drosophila melanogaster
Interactions: 133
UniProt ID: Q8SY39

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1261333

Q7JQN4
RNA helicase

2

18

High-throughput

0.737

High

1344123

DDX18
Probable ATP-dependent RNA helicase pitchoune

2

19

High-throughput

0.737

High

1344138

DDX47
ATP-dependent RNA helicase DDX47

2

19

High-throughput

0.737

High

614089

SGG
Protein kinase shaggy

2

9

High-throughput

0.635

High

263484

O61380
Eukaryotic translation initiation factor 4G1, isoform A

1

5

High-throughput

0.575

High

356799

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

17

High-throughput

0.575

High

654289

DDX6
ATP-dependent RNA helicase me31b

1

17

High-throughput

0.575

High

1173914

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

20

High-throughput

0.575

High

1237368

Q6NQY9
ATP-dependent RNA helicase

1

17

High-throughput

0.575

High

1266510

Q7K4L8
RNA helicase

1

15

High-throughput

0.575

High

1285356

Y8611
Probable ATP-dependent RNA helicase CG8611

1

18

High-throughput

0.575

High

1344127

INO80
Chromatin-remodeling ATPase INO80

1

12

High-throughput

0.575

High

1344139

Q9VJ74
Probable ATP-dependent RNA helicase DDX23

1

19

High-throughput

0.575

High

1344153

Q9VRI0
Probable ATP-dependent RNA helicase DDX56

1

20

High-throughput

0.575

High

1344167

RENT1
Regulator of nonsense transcripts 1 homolog

1

10

High-throughput

0.575

High

54882

A1Z909
LD11307p

2

10

High-throughput

0.571

High

304803

O76994
Ribosome biogenesis protein NSA2 homolog

2

2

High-throughput

0.571

High

1268855

NHK1
Nucleosomal histone kinase 1

2

11

High-throughput

0.571

High

1344108

NOG1
Nucleolar GTP-binding protein 1

2

11

High-throughput

0.571

High

1344137

NOC3L
Nucleolar complex protein 3

2

12

High-throughput

0.571

High

1344150

Q9VM69
Nucleolar protein 58

2

9

High-throughput

0.571

High

1344164

Q9VXK5
Putative rRNA methyltransferase

2

8

High-throughput

0.571

High

1344171

Q9VZF5
Kinesin-like protein

2

11

High-throughput

0.571

High

1344180

NAT10
RNA cytidine acetyltransferase

2

2

High-throughput

0.571

High

95231

E1JIH4
Uncharacterized protein, isoform D

2

1

High-throughput

0.521

High

1069742

Q0E931
GTP-binding protein 1

2

7

High-throughput

0.521

High

1344125

Q9VDK7
Signal recognition particle subunit SRP72

2

3

High-throughput

0.521

High

1344130

Q9VEP0
Regulatory protein zeste

2

1

High-throughput

0.521

High

1344152

Q9VQI5
Interferon-related developmental regulator 1

2

1

High-throughput

0.521

High

786375

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

4

High-throughput

0.514

High

1344148

Y3096
Ribosomal L1 domain-containing protein CG13096

1

7

High-throughput

0.514

High

1321616

GNL3
Guanine nucleotide-binding protein-like 3 homolog

1

9

High-throughput

0.479

High

55785

A1Z9K0
Uncharacterized protein, isoform B

1

10

High-throughput

0.445

High

58089

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.445

High

263384

PENG
Protein penguin

1

5

High-throughput

0.445

High

704366

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

6

High-throughput

0.445

High

718341

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.445

High

852943

ACTZ
Actin-related protein 1

1

4

High-throughput

0.445

High

861438

KL61
Kinesin-like protein Klp61F

1

5

High-throughput

0.445

High

875231

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.445

High

1175996

MCM4
DNA replication licensing factor MCM4

1

10

High-throughput

0.445

High

1263207

Q7JXU4
Nucleolar GTP-binding protein 2

1

9

High-throughput

0.445

High

1265141

RRP8
Ribosomal RNA-processing protein 8

1

2

High-throughput

0.445

High

1265725

Q7K3H0
LD28067p

1

2

High-throughput

0.445

High

1302220

Q8I937
Ribosome biogenesis regulatory protein

1

3

High-throughput

0.445

High

1302811

NOL6
Nucleolar protein 6

1

1

High-throughput

0.445

High

1321430

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.445

High

1344102

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

3

High-throughput

0.445

High

1344103

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.445

High

1344104

Q95WY3
Nucleolar protein 56

1

9

High-throughput

0.445

High

1344105

Q9V3V6
26S proteasome regulatory complex subunit p50

1

15

High-throughput

0.445

High

1344106

Q9V405
26S proteasome regulatory subunit 6B

1

8

High-throughput

0.445

High

1344109

API5
Apoptosis inhibitor 5 homolog

1

3

High-throughput

0.445

High

1344110

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.445

High

1344112

CLAMP
Transcription factor Clamp

1

2

High-throughput

0.445

High

1344114

Q9V9U9
Nucleolar protein 16

1

1

High-throughput

0.445

High

1344115

EBP2
Probable rRNA-processing protein EBP2 homolog

1

3

High-throughput

0.445

High

1344116

Q9VAH7
N-terminal kinase-like protein

1

8

High-throughput

0.445

High

1344118

LARP
La-related protein 1

1

11

High-throughput

0.445

High

1344120

RRP5
rRNA biogenesis protein RRP5

1

13

High-throughput

0.445

High

1344122

Q9VCY1
RRM domain-containing protein

1

12

High-throughput

0.445

High

1344126

SURF6
Surfeit locus protein 6 homolog

1

3

High-throughput

0.445

High

1344128

RPF2
Ribosome production factor 2 homolog

1

2

High-throughput

0.445

High

1344131

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

12

High-throughput

0.445

High

1344134

RLP24
Probable ribosome biogenesis protein RLP24

1

7

High-throughput

0.445

High

1344140

Q9VJG2
RRM domain-containing protein

1

20

High-throughput

0.445

High

1344141

Q9VJH2
Aspartyl-tRNA synthetase, mitochondrial, isoform A

1

5

High-throughput

0.445

High

1344142

RRP1L
Ribosomal RNA processing protein 1 homolog

1

9

High-throughput

0.445

High

1344143

RPF1
Probable ribosome production factor 1

1

8

High-throughput

0.445

High

1344144

Q9VKC1
IP16805p

1

11

High-throughput

0.445

High

1344147

PESC
Pescadillo homolog

1

5

High-throughput

0.445

High

1344154

SRP68
Signal recognition particle subunit SRP68

1

3

High-throughput

0.445

High

1344157

Q9VTF8
Mitochondrial ribosomal protein L2

1

10

High-throughput

0.445

High

1344158

KRI1
Protein KRI1 homolog

1

3

High-throughput

0.445

High

1344165

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1344166

Q9VXR5
ATP-binding cassette sub-family F member 2

1

6

High-throughput

0.445

High

1344168

Q9VZ88
AT07585p

1

14

High-throughput

0.445

High

1344170

BRX1
Ribosome biogenesis protein BRX1 homolog

1

11

High-throughput

0.445

High

1344175

Q9W0R0
Cell division cycle 5, isoform A

1

7

High-throughput

0.445

High

1344176

Q9W0T7
Dis3 like 3'-5' exoribonuclease 2, isoform A

1

6

High-throughput

0.445

High

1344177

Q9W124
LD27920p

1

11

High-throughput

0.445

High

1344178

Q9W1G1
Uncharacterized protein, isoform A

1

1

High-throughput

0.445

High

1344179

Q9W3B2
Protein MAK16 homolog

1

3

High-throughput

0.445

High

1344181

NOP53
Ribosome biogenesis protein NOP53

1

6

High-throughput

0.445

High

1344182

Q9W414
Regulatory particle triple-A ATPase 4

1

7

High-throughput

0.445

High

1344186

SYQ
Probable glutamine--tRNA ligase

1

4

High-throughput

0.445

High

118961

M9NFI9
Neurabin-1

1

6

High-throughput

0.442

High

55633

A1Z9I5
Rac GTPase-activating protein 1

1

7

High-throughput

0.437

High

1344121

Q9VCC9
LD23779p

1

9

High-throughput

0.437

High

1237079

Q6NPA6
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.426

High

1344133

Q9VG84
DNA ligase

1

0

High-throughput

0.426

High

1344151

Q9VN39
RE74585p

1

0

High-throughput

0.426

High

1344184

Q9W4C4
GM14014p

1

0

High-throughput

0.426

High

2480

NOVA
RNA-binding protein Pasilla

1

13

High-throughput

0.407

High

53136

A1Z7K8
AaRS-interacting multifunctional protein 1

1

1

High-throughput

0.407

High

55443

A1Z9E3
Elongation factor Tu

1

3

High-throughput

0.407

High

264416

O62530
Adaptor protein complex 2, mu subunit, isoform A

1

3

High-throughput

0.407

High

360551

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.407

High

782734

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

5

High-throughput

0.407

High

834853

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

4

High-throughput

0.407

High

852195

COPB
Coatomer subunit beta

1

2

High-throughput

0.407

High

1057335

ARL2
ADP-ribosylation factor-like protein 2

1

3

High-throughput

0.407

High

1234096

SARM1
NAD(+) hydrolase sarm1

1

8

High-throughput

0.407

High

1261121

Q7JN06
Boundary element associated factor

1

1

High-throughput

0.407

High

1268336

DYM
Dymeclin

1

1

High-throughput

0.407

High

1321079

Q8MRH0
RE37229p

1

8

High-throughput

0.407

High

1344101

Q8SY53
GH11935p

1

4

High-throughput

0.407

High

1344111

Q9V455
Importin subunit alpha

1

3

High-throughput

0.407

High

1344113

Q9V9Q4
LD43819p

1

1

High-throughput

0.407

High

1344117

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

5

High-throughput

0.407

High

1344119

Q9VAX8
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.407

High

1344124

PPAN
Protein Peter pan

1

7

High-throughput

0.407

High

1344129

Q9VEH0
Aluminum tubes, isoform A

1

13

High-throughput

0.407

High

1344135

IPO9
Importin-9

1

12

High-throughput

0.407

High

1344136

Q9VI53
LD44267p

1

9

High-throughput

0.407

High

1344145

NFS1
Cysteine desulfurase, mitochondrial

1

1

High-throughput

0.407

High

1344146

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

High-throughput

0.407

High

1344149

Q9VM57
Septin interacting protein 2, isoform A

1

1

High-throughput

0.407

High

1344156

Q9VT61
Ciz1 zinc finger protein, isoform A

1

2

High-throughput

0.407

High

1344159

FRL
Formin-like protein

1

1

High-throughput

0.407

High

1344160

Q9VUH8
Survival of motor neuron-related-splicing factor 30

1

4

High-throughput

0.407

High

1344161

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

3

High-throughput

0.407

High

1344162

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.407

High

1344163

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

3

High-throughput

0.407

High

1344169

Q9VZE4
RE70333p

1

11

High-throughput

0.407

High

1344172

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.407

High

1344173

Q9W0E4
Aminopeptidase

1

6

High-throughput

0.407

High

1344174

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.407

High

1344185

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

2

High-throughput

0.407

High

1344107

Q9V406
Activator protein 4

1

0

High-throughput

0.249

Low

1344132

RRP15
RRP15-like protein

1

0

High-throughput

0.232

Low

1344155

Q9VT38
GH03795p

1

0

High-throughput

0.232

Low

1344183

Q9W4C1
IP13321p

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025