HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: CAV1 (Q03135)
Caveolin-1
Gene: CAV1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31871319, 20460433
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0030335 - positive regulation of cell migration GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 178
+	Hs
		961974 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		988301 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Mm
		890920 RAC1_MOUSE (1-193): 6.84e-81: 240: 57.22		CAV1_MOUSE (1-178): 4.65e-108: 308: 94.94
+	Hs
		1015381 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		955079 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		581003 RAC2_HUMAN (1-193): 2.92e-77: 231: 54.12		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		953403 RAC3_HUMAN (1-179): 7.81e-75: 225: 57.54		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		977951 RHOB_HUMAN (1-191): 6.1e-74: 222: 84.82		CAV1_HUMAN (1-178): 2.83e-109: 310: 100.00
+	Hs
		905738 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		CAV2_HUMAN (53-177): 5.12e-59: 183: 40.80
+	Hs
		905735 RHOB_HUMAN (1-191): 6.1e-74: 222: 84.82		CAV2_HUMAN (53-177): 5.12e-59: 183: 40.80