Protein: KLH23
Kelch-like protein 23

Gene: KLH23, KLHL23
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q8NBE8

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113719

CUL3
Cullin-3

9

20

Small-scale

0.968

High

568260

PLST
Plastin-3

2

1

High-throughput

0.628

High

965783

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

3

High-throughput

0.628

High

1308557

NUDC3
NudC domain-containing protein 3

2

20

High-throughput

0.628

High

1153414

CD226
CD226 antigen

1

1

High-throughput

0.618

High

1333283

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

20

High-throughput

0.618

High

468600

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.584

High

1333284

FXL17
F-box/LRR-repeat protein 17

1

15

High-throughput

0.575

High

890667

RGS3
Regulator of G-protein signaling 3

2

3

High-throughput

0.574

High

1333282

OSBL5
Oxysterol-binding protein-related protein 5

2

4

High-throughput

0.574

High

1219928

BSPRY
B box and SPRY domain-containing protein

1

4

High-throughput

0.536

High

1333279

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

1333280

DCNL1
DCN1-like protein 1

1

9

High-throughput

0.536

High

1333285

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

High-throughput

0.536

High

822762

VHL
von Hippel-Lindau disease tumor suppressor

1

4

High-throughput

0.515

High

51366

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

1

0

High-throughput

0.513

High

1059232

TISB
mRNA decay activator protein ZFP36L1

1

0

High-throughput

0.513

High

402972

ANXA1
Annexin A1

1

1

High-throughput

0.508

High

627993

ANXA7
Annexin A7

1

1

High-throughput

0.508

High

681875

RBTN2
Rhombotin-2

1

6

High-throughput

0.489

High

808119

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

346077

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

461712

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

405512

KITH
Thymidine kinase, cytosolic

1

2

High-throughput

0.464

High

1272489

CSN6
COP9 signalosome complex subunit 6

1

10

High-throughput

0.445

High

162109

ACOT8
Acyl-coenzyme A thioesterase 8

3

0

High-throughput

0.347

High

1333281

HUTI
Probable imidazolonepropionase

3

0

High-throughput

0.342

High

139567

PESC
Pescadillo homolog

2

0

High-throughput

0.328

High

709300

CCN2
CCN family member 2

2

0

High-throughput

0.328

High

1196884

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

0

High-throughput

0.328

High

1332461

SAXO5
Stabilizer of axonemal microtubules 5

1

0

High-throughput

0.279

Low

1333278

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.279

Low

239378

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025