HitPredict

Interactor 1: H2A1 (P0C0S8)
Histone H2A type 1 (H2A.1) (Histone H2A/ptl)
Gene: H2AC11

Interactor 2: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 130 Hs			1 355
+	Hs
		391795 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		1236442 H2A1H_HUMAN (1-128): 4.17e-67: 200: 100.00		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		1216227 H2A2B_HUMAN (1-130): 2.11e-66: 198: 94.62		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		1087052 H2A2C_HUMAN (1-130): 3.65e-65: 195: 96.92		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		1216244 H2A2B_HUMAN (1-130): 2.11e-66: 198: 94.62		SIR1_HUMAN (25-336): 3.35e-99: 311: 21.83
+	Hs
		391782 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		SIR2_HUMAN (31-318): 3.2e-102: 308: 22.12
+	Hs
		1087112 H2A2C_HUMAN (1-130): 3.65e-65: 195: 96.92		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61
+	Hs
		555660 H2AX_HUMAN (1-129): 8.34e-64: 192: 91.47		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61
+	Sc
		392239 H2A2_YEAST (16-128): 2.5e-59: 180: 80.53		SIR2_YEAST (33-288): 1.59e-86: 273: 20.00
+	Sc
		392014 H2A1_YEAST (16-127): 4.04e-53: 165: 81.25		SIR2_YEAST (33-288): 1.59e-86: 273: 20.00