Protein: RPA2
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)

Gene: RPA2, POLR1B
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9H9Y6

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340037

RPA1
DNA-directed RNA polymerase I subunit RPA1

11

20

Small-scale

0.975

High

180403

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

17

High-throughput

0.903

High

959059

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

8

High-throughput

0.903

High

1185170

RPA43
DNA-directed RNA polymerase I subunit RPA43

4

1

High-throughput

0.903

High

983709

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

9

High-throughput

0.892

High

1428629

RPA49
DNA-directed RNA polymerase I subunit RPA49

4

5

Small-scale

0.886

High

191101

RPA34
DNA-directed RNA polymerase I subunit RPA34

3

3

High-throughput

0.847

High

923542

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

6

High-throughput

0.789

High

1437318

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

2

Small-scale

0.789

High

1437319

RPA12
DNA-directed RNA polymerase I subunit RPA12

2

13

High-throughput

0.789

High

516870

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

9

High-throughput

0.712

High

621971

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

10

High-throughput

0.704

High

620593

NUCL
Nucleolin

1

1

High-throughput

0.691

High

729457

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.691

High

1292810

SKAP1
Src kinase-associated phosphoprotein 1

3

3

High-throughput

0.667

High

165094

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

20

High-throughput

0.618

High

192858

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

3

High-throughput

0.618

High

287478

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

3

High-throughput

0.618

High

621753

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

17

High-throughput

0.618

High

667461

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

20

High-throughput

0.618

High

723097

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

10

High-throughput

0.618

High

787791

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

12

High-throughput

0.618

High

912237

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

9

High-throughput

0.618

High

976153

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

11

High-throughput

0.618

High

1437314

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

3

High-throughput

0.618

High

1437315

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

10

High-throughput

0.618

High

1437328

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

12

High-throughput

0.618

High

1437329

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

11

High-throughput

0.618

High

411060

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

Small-scale

0.611

High

912129

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

6

High-throughput

0.611

High

1437326

GPN3
GPN-loop GTPase 3

3

13

High-throughput

0.609

High

907584

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

0

High-throughput

0.585

High

589725

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

696545

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

769213

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

396976

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

223561

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

1

High-throughput

0.541

High

664816

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.541

High

1436777

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.541

High

1437322

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.541

High

911381

IMA5
Importin subunit alpha-5

1

5

High-throughput

0.536

High

1291221

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

1382535

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

1436798

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.536

High

1437310

GPN1
GPN-loop GTPase 1

1

13

High-throughput

0.536

High

964156

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.518

High

1122443

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.518

High

1287931

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.518

High

334247

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

732707

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

1136758

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.513

High

1381285

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.513

High

1434627

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.513

High

1437323

TRI10
Tripartite motif-containing protein 10

1

0

High-throughput

0.513

High

1328764

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.494

High

904125

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.493

High

262134

NBN
Nibrin

1

0

Small-scale

0.479

High

129445

MEN1
Menin

1

1

High-throughput

0.479

High

157868

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

316441

RMP
Unconventional prefoldin RPB5 interactor 1

1

3

High-throughput

0.479

High

331334

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

346354

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

373182

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

412632

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

430647

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

3

High-throughput

0.479

High

487768

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

594106

NCK1
SH2/SH3 adapter protein NCK1

1

2

High-throughput

0.479

High

644068

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

699861

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.479

High

861784

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

Small-scale

0.479

High

879476

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

897399

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.479

High

959256

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.479

High

987952

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.479

High

1100398

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1105095

TCOF
Treacle protein

1

1

Small-scale

0.479

High

1106078

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1138073

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1140883

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1151501

IKBB
NF-kappa-B inhibitor beta

1

2

High-throughput

0.479

High

1161680

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1178386

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1215839

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1217616

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

11

High-throughput

0.479

High

1255591

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1313053

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

3

High-throughput

0.479

High

1329878

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1367310

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1397441

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1399353

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

13

High-throughput

0.479

High

1435168

RPAP3
RNA polymerase II-associated protein 3

1

7

High-throughput

0.479

High

1435305

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1437309

RC3H2
Roquin-2

1

5

High-throughput

0.479

High

1437311

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

14

High-throughput

0.479

High

1437312

ANLN
Anillin

1

1

High-throughput

0.479

High

1437320

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

1437321

UXT
Protein UXT

1

2

High-throughput

0.479

High

1437324

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1437325

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.479

High

728624

AKT2
RAC-beta serine/threonine-protein kinase

1

0

High-throughput

0.460

High

123837

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

248094

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

898829

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

996540

ACTS
Actin, alpha skeletal muscle

1

0

Small-scale

0.458

High

1134540

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

Small-scale

0.458

High

1352761

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1385628

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

516805

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

1292291

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

1326093

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

182186

PFD6
Prefoldin subunit 6

1

4

High-throughput

0.437

High

294344

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1232022

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

2

High-throughput

0.437

High

1398612

DAA10
Dynein axonemal assembly factor 10

1

3

High-throughput

0.437

High

1437313

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.437

High

1437316

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

1437327

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

1290267

Q86V94
LOC554223 protein

2

0

High-throughput

0.318

High

1192208

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1207267

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1216406

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1332570

TEX19
Testis-expressed protein 19

1

0

High-throughput

0.279

Low

1163761

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.249

Low

1437317

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.249

Low

1411146

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.232

Low

1430425

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025