HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 567
+	Sp
		151786 RU17_SCHPO (1-277): 2.15e-51: 175: 38.27		DSK1_SCHPO (3-565): 1.11e-108: 337: 35.27
+	Hs
		550125 PABP1_HUMAN (4-361): 7.87e-51: 183: 11.08		CDK2_HUMAN (276-566): 7.06e-82: 259: 18.09
+	Hs
		550226 PABP1_HUMAN (4-361): 7.87e-51: 183: 11.08		SRPK2_HUMAN (297-566): 1.58e-71: 244: 57.69
+	Hs
		472627 RU17_HUMAN (1-437): 4.45e-47: 169: 100.00		SRPK2_HUMAN (297-566): 1.58e-71: 244: 57.69
+	Hs
		1006429 U1SBP_HUMAN (83-301): 7.93e-48: 166: 40.46		SRPK2_HUMAN (297-566): 1.58e-71: 244: 57.69
+	Hs
		550181 PABP1_HUMAN (4-361): 7.87e-51: 183: 11.08		CLK2_HUMAN (60-227): 1.4e-63: 218: 32.54
+	Hs
		668090 RBM7_HUMAN (96-357): 8.57e-36: 134: 18.73		CDK2_HUMAN (276-566): 7.06e-82: 259: 18.09
+	Hs
		550424 PABP1_HUMAN (4-361): 7.87e-51: 183: 11.08		SRPK1_HUMAN (368-566): 3.87e-59: 209: 67.84
+	Hs
		116970 J3KPD3_HUMAN (96-357): 1.05e-34: 131: 17.91		CDK2_HUMAN (276-566): 7.06e-82: 259: 18.09
+	Hs
		472532 RU17_HUMAN (1-437): 4.45e-47: 169: 100.00		CLK2_HUMAN (60-227): 1.4e-63: 218: 32.54
+	Hs
		473000 RU17_HUMAN (1-437): 4.45e-47: 169: 100.00		SRPK1_HUMAN (368-566): 3.87e-59: 209: 67.84
+	Hs
		889633 PABP5_HUMAN (4-350): 1.78e-34: 134: 11.41		CLK2_HUMAN (60-227): 1.4e-63: 218: 32.54
+	Hs
		889686 RBM7_HUMAN (96-357): 8.57e-36: 134: 18.73		CLK2_HUMAN (60-227): 1.4e-63: 218: 32.54
+	Rn
		640080 PABP1_RAT (4-361): 1.37e-50: 182: 11.08		MK03_RAT (75-267): 2.41e-44: 163: 20.90
+	Rn
		81584 B5DF80_RAT (4-361): 5.77e-48: 175: 10.55		MK03_RAT (75-267): 2.41e-44: 163: 20.90
+	Hs
		550182 PABP1_HUMAN (4-361): 7.87e-51: 183: 11.08		CLK3_HUMAN (396-565): 3.62e-13: 73.9: 25.97
+	Hs
		472533 RU17_HUMAN (1-437): 4.45e-47: 169: 100.00		CLK3_HUMAN (396-565): 3.62e-13: 73.9: 25.97
+	Hs
		889742 U1SBP_HUMAN (83-301): 7.93e-48: 166: 40.46		CLK3_HUMAN (396-565): 3.62e-13: 73.9: 25.97
+	Hs
		889786 PABP5_HUMAN (4-350): 1.78e-34: 134: 11.41		CLK3_HUMAN (396-565): 3.62e-13: 73.9: 25.97
+	Hs
		889723 PABP4_HUMAN (2-293): 9.81e-32: 129: 10.88		CLK3_HUMAN (396-565): 3.62e-13: 73.9: 25.97