HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 184
+	Sc
		350834 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		YPT1_YEAST (4-178): 3.04e-73: 221: 28.41
+	Rn
		936845 UBC_RAT (1-181): 2.6e-61: 206: 96.13		RAB8B_RAT (7-180): 5.06e-86: 253: 30.11
+	Rn
		102473 UBC_RAT (1-181): 2.6e-61: 206: 96.13		G3V6H0_RAT (4-173): 4.57e-75: 225: 30.41
+	At
		656930 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		RAD2A_ARATH (4-180): 2.09e-78: 233: 29.78
+	At
		1091637 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		RAB1B_ARATH (1-170): 1.76e-75: 226: 31.58
+	At
		955321 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		RAB1C_ARATH (1-170): 3.45e-74: 223: 31.58
+	Hs
		397887 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Rn
		930590 UBC_RAT (1-181): 2.6e-61: 206: 96.13		RALA_RAT (8-171): 7.02e-31: 113: 34.94
+	Xl
		1186348 Q7SY79_XENLA (1-153): 1.14e-53: 183: 99.35		Q7ZX67_XENLA (19-183): 3.31e-33: 118: 38.24
+	Xl
		923943 UBIQP_XENLA (1-152): 2.24e-58: 183: 100.00		Q7ZX67_XENLA (19-183): 3.31e-33: 118: 38.24
+	Hs
		476617 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RAP2C_HUMAN (19-164): 5.1e-31: 112: 39.04