HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: RN19B (Q6ZMZ0)
E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)
Gene: RNF19B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	IBR~ubiquitin
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 732
+	Hs
		475939 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN19B_HUMAN (1-732): 0: 976: 100.00
+	Hs
		312457 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		ARI2_HUMAN (106-346): 5.48e-72: 244: 22.13
+	Hs
		475094 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		CUL9_HUMAN (108-346): 9.14e-63: 230: 24.59
+	Sc
		477225 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		HEL1_YEAST (115-345): 4.84e-62: 219: 24.79
+	Hs
		226334 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		PRKN_HUMAN (83-330): 2.95e-55: 198: 20.30
+	Dm
		1214032 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		LUBEL_DROME (118-321): 1.46e-45: 178: 22.32
+	Hs
		476630 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		ARI1_HUMAN (92-346): 4.15e-78: 262: 23.28
+	Hs
		475976 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		R144B_HUMAN (113-380): 9.6e-81: 261: 24.63
+	Hs
		475494 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		R144A_HUMAN (114-380): 9.13e-77: 250: 26.84
+	Hs
		312458 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		ARI2_HUMAN (106-346): 5.48e-72: 244: 22.13
+	Hs
		476496 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		AKIB1_HUMAN (73-343): 2.38e-66: 239: 21.16
+	Rn
		1144287 UBC_RAT (1-181): 2.6e-61: 206: 96.13		PRKN_RAT (83-330): 1.5e-55: 199: 20.30
+	Mm
		477054 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		HOIL1_MOUSE (55-317): 5.33e-55: 198: 24.47
+	Hs
		476320 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		HOIL1_HUMAN (55-317): 4.28e-60: 212: 25.23
+	Hs
		226335 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		PRKN_HUMAN (83-330): 2.95e-55: 198: 20.30
+	Dm
		477528 UBIQP_DROME (1-154): 5.32e-53: 183: 99.35		LUBEL_DROME (118-321): 1.46e-45: 178: 22.32
+	Hs
		227107 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		PRKN_HUMAN (83-330): 2.95e-55: 198: 20.30
+	Hs
		171468 UBD_HUMAN (79-228): 1.03e-29: 110: 31.41		PRKN_HUMAN (83-330): 2.95e-55: 198: 20.30
+	Hs
		226251 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		PRKN_HUMAN (83-330): 2.95e-55: 198: 20.30