HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBE3B (Q7Z3V4)
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
Gene: UBE3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 1068
+	Mm
		477022 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE3B_MOUSE (1-1068): 0: 1416: 92.15
+	Mm
		476866 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE3C_MOUSE (6-1068): 0: 595: 25.83
+	Hs
		474953 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		NEDD4_HUMAN (604-1066): 1.95e-158: 505: 28.54
+	Hs
		475140 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125112 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		475799 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE3C_HUMAN (6-1068): 0: 579: 25.55
+	Sp
		143368 UBI4P_SCHPO (1-228): 2.98e-90: 272: 96.05		PTR1_SCHPO (467-1068): 1.68e-145: 485: 24.49
+	Hs
		475080 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		HUWE1_HUMAN (608-1068): 7.34e-141: 471: 30.02
+	Hs
		475196 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		SMUF2_HUMAN (646-1065): 1.38e-150: 468: 27.25
+	Sc
		477293 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		RSP5_YEAST (604-1066): 8.12e-154: 479: 27.31
+	Dm
		1376481 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		Q9W325_DROME (645-1067): 1.52e-140: 431: 29.81
+	Rn
		1140970 UBC_RAT (1-181): 2.6e-61: 206: 96.13		Q5YB86_RAT (604-1066): 6.44e-162: 501: 27.80
+	Hs
		475470 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		NEDD4_HUMAN (604-1066): 1.95e-158: 505: 28.54
+	Hs
		476205 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125113 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Mm
		476858 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		HUWE1_MOUSE (608-1068): 2.36e-140: 470: 30.02
+	Mm
		476846 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		HERC4_MOUSE (509-1067): 1.05e-140: 451: 21.95
+	Hs
		475984 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		HUWE1_HUMAN (608-1068): 7.34e-141: 471: 30.02
+	Sc
		477380 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		HUL5_YEAST (509-1068): 4.5e-64: 236: 31.46
+	Hs
		475963 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		HECW1_HUMAN (678-1067): 4.12e-46: 183: 33.08