HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	28190767, 38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 937
+	Hs
		321470 UBC_HUMAN (1-685): 0: 846: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302094 UBC_HUMAN (1-685): 0: 846: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		475514 UBC_HUMAN (1-685): 0: 846: 100.00		COPB_HUMAN (8-927): 0: 561: 12.47
+	Zm
		111864 Q42415_MAIZE (229-685): 0: 548: 95.84		K7VAA4_MAIZE (13-808): 1.26e-178: 541: 15.95
+	Mm
		477012 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Rn
		923858 UBC_RAT (1-108): 1.27e-29: 127: 90.74		AP2B1_RAT (1-937): 0: 926: 100.00
+	At
		286688 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		APBLC_ARATH (3-936): 0: 756: 56.46
+	At
		1092397 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		APBLB_ARATH (3-936): 0: 750: 56.14
+	Zm
		111863 Q41754_MAIZE (381-685): 3.03e-124: 375: 95.74		K7VAA4_MAIZE (13-808): 1.26e-178: 541: 15.95
+	At
		1092398 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		COPB1_ARATH (6-919): 0: 562: 13.63
+	At
		1091811 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AP2A2_ARATH (13-934): 0: 554: 15.90
+	At
		1013363 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		COPG_ARATH (3-933): 4.18e-175: 533: 14.06
+	At
		1091731 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AP1G1_ARATH (14-809): 2.91e-173: 527: 16.34
+	At
		1092096 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		APBLA_ARATH (12-741): 3.83e-165: 505: 30.21
+	Mm
		476683 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		AP2A1_MOUSE (11-932): 0: 633: 17.04
+	Hs
		321462 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Mm
		476684 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		AP2A2_MOUSE (11-932): 0: 596: 16.50
+	Rn
		1144175 UBC_RAT (1-108): 1.27e-29: 127: 90.74		Q66HM2_RAT (11-932): 0: 590: 16.38
+	Hs
		302089 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		863195 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		COPB_HUMAN (8-927): 0: 561: 12.47