Protein: MED15
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)

Gene: MED15
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q96RN5

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1301096

MED29
Mediator of RNA polymerase II transcription subunit 29

4

2

High-throughput

0.903

High

1301101

MED23
Mediator of RNA polymerase II transcription subunit 23

4

3

Small-scale

0.886

High

1301102

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

Small-scale

0.827

High

826339

CDK8
Cyclin-dependent kinase 8

14

11

Small-scale

0.762

High

48714

MED19
Mediator of RNA polymerase II transcription subunit 19

7

1

High-throughput

0.750

High

265355

MED24
Mediator of RNA polymerase II transcription subunit 24

2

0

High-throughput

0.748

High

1076189

MED1
Mediator of RNA polymerase II transcription subunit 1

7

7

Small-scale

0.746

High

1301089

CDK19
Cyclin-dependent kinase 19

6

10

Small-scale

0.733

High

738989

SRBP1
Sterol regulatory element-binding protein 1

5

12

Small-scale

0.721

High

206641

MED7
Mediator of RNA polymerase II transcription subunit 7

5

4

Small-scale

0.718

High

1274333

MED12
Mediator of RNA polymerase II transcription subunit 12

5

10

Small-scale

0.714

High

1301093

MED4
Mediator of RNA polymerase II transcription subunit 4

4

2

High-throughput

0.699

High

313459

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

Small-scale

0.694

High

1301087

MED10
Mediator of RNA polymerase II transcription subunit 10

4

2

Small-scale

0.694

High

1301088

MED18
Mediator of RNA polymerase II transcription subunit 18

4

1

High-throughput

0.694

High

225410

MED14
Mediator of RNA polymerase II transcription subunit 14

4

12

Small-scale

0.686

High

624493

CCNC
Cyclin-C

4

2

High-throughput

0.686

High

1301090

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

1037088

MED21
Mediator of RNA polymerase II transcription subunit 21

3

2

High-throughput

0.675

High

1301092

MED20
Mediator of RNA polymerase II transcription subunit 20

3

1

High-throughput

0.667

High

1301095

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

High-throughput

0.664

High

1301094

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

Small-scale

0.656

High

1290871

TRI11
E3 ubiquitin-protein ligase TRIM11

3

9

Small-scale

0.650

High

1301099

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

Small-scale

0.650

High

270525

MED6
Mediator of RNA polymerase II transcription subunit 6

3

2

Small-scale

0.640

High

1174954

MED25
Mediator of RNA polymerase II transcription subunit 25

3

3

Small-scale

0.640

High

868699

ATX1
Ataxin-1

2

4

High-throughput

0.628

High

1074720

MED22
Mediator of RNA polymerase II transcription subunit 22

2

1

High-throughput

0.611

High

1158914

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.611

High

1301097

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

1301103

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.602

High

1078631

SMAD2
Mothers against decapentaplegic homolog 2

2

16

Small-scale

0.601

High

791888

HD
Huntingtin

2

4

High-throughput

0.596

High

244818

BRD4
Bromodomain-containing protein 4

2

10

High-throughput

0.584

High

370253

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

170126

PLS1
Phospholipid scramblase 1

1

2

High-throughput

0.541

High

876616

AF17
Protein AF-17

1

3

High-throughput

0.541

High

1044685

FHL3
Four and a half LIM domains protein 3

1

12

High-throughput

0.541

High

117800

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.536

High

486312

CCL3
C-C motif chemokine 3

1

1

High-throughput

0.536

High

896524

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

High-throughput

0.536

High

985684

CTSL2
CTD small phosphatase-like protein 2

1

1

High-throughput

0.536

High

1085648

HIF1A
Hypoxia-inducible factor 1-alpha

1

16

Small-scale

0.536

High

1160884

FXL19
F-box/LRR-repeat protein 19

1

4

High-throughput

0.536

High

1251892

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.536

High

1293695

MED30
Mediator of RNA polymerase II transcription subunit 30

1

2

High-throughput

0.536

High

831612

CEBPA
CCAAT/enhancer-binding protein alpha

1

17

High-throughput

0.527

High

736028

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.518

High

950253

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.515

High

973385

TOP2B
DNA topoisomerase 2-beta

1

3

High-throughput

0.515

High

1078747

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.515

High

897610

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

913941

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

978859

TF65
Transcription factor p65

1

12

Small-scale

0.501

High

1301105

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

Small-scale

0.501

High

1016095

SRBP2
Sterol regulatory element-binding protein 2

1

15

Small-scale

0.500

High

1301104

TRRAP
Transformation/transcription domain-associated protein

1

5

Small-scale

0.484

High

175915

P73
Tumor protein p73

1

13

Small-scale

0.479

High

197807

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

266414

TAD2A
Transcriptional adapter 2-alpha

1

8

High-throughput

0.479

High

318704

EYA4
Eyes absent homolog 4

1

16

High-throughput

0.479

High

377617

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

476236

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.479

High

487696

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

565004

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

High-throughput

0.479

High

652015

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

668920

PML
Protein PML

1

11

High-throughput

0.479

High

721216

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

808866

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

875242

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

967375

EWS
RNA-binding protein EWS

1

10

High-throughput

0.479

High

980848

TLE3
Transducin-like enhancer protein 3

1

16

High-throughput

0.479

High

1018256

NFIA
Nuclear factor 1 A-type

1

10

High-throughput

0.479

High

1019093

TP53B
TP53-binding protein 1

1

13

High-throughput

0.479

High

1032566

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.479

High

1035561

SMAD4
Mothers against decapentaplegic homolog 4

1

17

Small-scale

0.479

High

1042340

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1048190

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

9

Small-scale

0.479

High

1061330

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

High-throughput

0.479

High

1067105

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1076280

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

1132728

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

7

High-throughput

0.479

High

1171330

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1174770

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

1188749

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1200319

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

7

High-throughput

0.479

High

1244668

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1269415

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1281330

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

1291838

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

1299669

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1301086

EPAS1
Endothelial PAS domain-containing protein 1

1

16

Small-scale

0.479

High

1301098

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1301100

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1173754

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1221350

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1260877

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

517416

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

374728

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.445

High

1146756

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.437

High

1206154

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

17

High-throughput

0.437

High

91306

E5RFK5
Cyclin-C

1

2

High-throughput

0.407

High

329041

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

1301091

AL8A1
2-aminomuconic semialdehyde dehydrogenase

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024