Protein: K1C16
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)

Gene: K1C16, KRT16
Organism: Homo sapiens
Interactions: 209
UniProt ID: P08779

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002009 - morphogenesis of an epithelium
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

385222

K2C6A
Keratin, type II cytoskeletal 6A

3

20

High-throughput

0.843

High

437064

K2C8
Keratin, type II cytoskeletal 8

3

20

High-throughput

0.843

High

476258

K2C3
Keratin, type II cytoskeletal 3

3

20

High-throughput

0.843

High

476261

K2C5
Keratin, type II cytoskeletal 5

3

20

High-throughput

0.843

High

476274

K22E
Keratin, type II cytoskeletal 2 epidermal

3

20

High-throughput

0.843

High

476277

PERI
Peripherin

3

20

High-throughput

0.843

High

476299

K22O
Keratin, type II cytoskeletal 2 oral

3

20

High-throughput

0.843

High

227201

KRT86
Keratin, type II cuticular Hb6

2

20

High-throughput

0.783

High

407365

K2C1
Keratin, type II cytoskeletal 1

2

20

High-throughput

0.783

High

476281

K2C6C
Keratin, type II cytoskeletal 6C

2

20

High-throughput

0.783

High

476294

KRT83
Keratin, type II cuticular Hb3

2

20

High-throughput

0.783

High

476295

KRT85
Keratin, type II cuticular Hb5

2

20

High-throughput

0.783

High

476313

KRT81
Keratin, type II cuticular Hb1

2

20

High-throughput

0.783

High

476315

K2C72
Keratin, type II cytoskeletal 72

2

20

High-throughput

0.783

High

476328

K2C71
Keratin, type II cytoskeletal 71

2

20

High-throughput

0.783

High

476336

K2C79
Keratin, type II cytoskeletal 79

2

20

High-throughput

0.783

High

476339

K2C80
Keratin, type II cytoskeletal 80

2

20

High-throughput

0.783

High

476347

K2C74
Keratin, type II cytoskeletal 74

2

20

High-throughput

0.783

High

476351

K2C73
Keratin, type II cytoskeletal 73

2

20

High-throughput

0.783

High

476356

K2C78
Keratin, type II cytoskeletal 78

2

20

High-throughput

0.783

High

341728

K2C75
Keratin, type II cytoskeletal 75

2

20

High-throughput

0.757

High

407242

K2C6B
Keratin, type II cytoskeletal 6B

2

20

High-throughput

0.757

High

474423

VIME
Vimentin

2

20

Small-scale

0.754

High

451314

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.691

High

476323

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

476395

SYNCI
Syncoilin

1

20

High-throughput

0.691

High

476265

K2C4
Keratin, type II cytoskeletal 4

1

20

High-throughput

0.665

High

476380

TCHP
Trichoplein keratin filament-binding protein

3

20

Small-scale

0.663

High

476348

K2C1B
Keratin, type II cytoskeletal 1b

1

20

High-throughput

0.621

High

476402

KRT82
Keratin, type II cuticular Hb2

1

20

High-throughput

0.621

High

436771

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

475502

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.618

High

475734

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

476263

DESM
Desmin

1

20

High-throughput

0.618

High

476301

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

476401

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

476374

SGF29
SAGA-associated factor 29

3

7

High-throughput

0.607

High

169402

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

17

High-throughput

0.606

High

333283

SNAPN
SNARE-associated protein Snapin

2

6

High-throughput

0.606

High

352056

MBD3
Methyl-CpG-binding domain protein 3

2

4

High-throughput

0.606

High

353666

DRC4
Dynein regulatory complex subunit 4

2

4

High-throughput

0.606

High

476270

CCNC
Cyclin-C

2

8

High-throughput

0.606

High

476271

RBTN1
Rhombotin-1

2

15

High-throughput

0.606

High

476287

ARFP2
Arfaptin-2

2

5

High-throughput

0.606

High

476288

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

2

High-throughput

0.606

High

476302

CDK18
Cyclin-dependent kinase 18

2

5

High-throughput

0.606

High

476324

PKN1
Serine/threonine-protein kinase N1

2

11

High-throughput

0.606

High

476327

PUS10
tRNA pseudouridine synthase Pus10

2

1

High-throughput

0.606

High

476340

PPR18
Phostensin

2

10

High-throughput

0.606

High

476346

EPMIP
EPM2A-interacting protein 1

2

2

High-throughput

0.606

High

476355

CC146
Coiled-coil domain-containing protein 146

2

11

High-throughput

0.606

High

476363

CCHCR
Coiled-coil alpha-helical rod protein 1

2

17

High-throughput

0.606

High

476369

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

8

High-throughput

0.606

High

476375

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

5

High-throughput

0.606

High

476379

TS101
Tumor susceptibility gene 101 protein

2

7

High-throughput

0.606

High

476382

KIFC3
Kinesin-like protein KIFC3

2

14

High-throughput

0.606

High

476393

CARD9
Caspase recruitment domain-containing protein 9

2

10

High-throughput

0.606

High

476406

AIRIM
AFG2-interacting ribosome maturation factor

2

6

High-throughput

0.606

High

476412

DPOLL
DNA polymerase lambda

2

2

High-throughput

0.606

High

476413

CYH4
Cytohesin-4

2

5

High-throughput

0.606

High

476282

GBG10

2

5

High-throughput

0.553

High

476335

TTC23
Tetratricopeptide repeat protein 23

2

13

High-throughput

0.553

High

476358

TXLNB
Beta-taxilin

2

20

High-throughput

0.553

High

476360

USBP1
Harmonin-binding protein USHBP1

2

18

High-throughput

0.553

High

476361

CA216
UPF0500 protein C1orf216

2

9

High-throughput

0.553

High

476362

LNX1
E3 ubiquitin-protein ligase LNX

2

9

High-throughput

0.553

High

476377

CCD17
Coiled-coil domain-containing protein 17

2

1

High-throughput

0.553

High

476386

SEM4C
Semaphorin-4C

2

3

High-throughput

0.553

High

476403

KLC4
Kinesin light chain 4

2

16

High-throughput

0.553

High

387210

APOA1
Apolipoprotein A-I

1

2

High-throughput

0.536

High

389934

ALBU
Albumin

1

8

High-throughput

0.536

High

476259

CFTR
Cystic fibrosis transmembrane conductance regulator

1

20

High-throughput

0.536

High

476275

IF4A3
Eukaryotic initiation factor 4A-III

1

16

High-throughput

0.536

High

476276

TXLNA
Alpha-taxilin

1

20

High-throughput

0.536

High

476307

CUL1
Cullin-1

1

20

High-throughput

0.536

High

476308

CUL2
Cullin-2

1

20

High-throughput

0.536

High

476309

CUL3
Cullin-3

1

20

High-throughput

0.536

High

476310

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

476316

FL2D
Pre-mRNA-splicing regulator WTAP

1

8

High-throughput

0.536

High

476319

PLEC
Plectin

1

20

High-throughput

0.536

High

476320

PCM1
Pericentriolar material 1 protein

1

7

High-throughput

0.536

High

476321

NEDD8
Ubiquitin-like protein NEDD8

1

6

High-throughput

0.536

High

476325

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

476326

KIF7
Kinesin-like protein KIF7

1

3

High-throughput

0.536

High

476349

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

12

High-throughput

0.536

High

476350

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.536

High

476354

AMOL1
Angiomotin-like protein 1

1

20

High-throughput

0.536

High

476367

CSN5
COP9 signalosome complex subunit 5

1

17

High-throughput

0.536

High

476381

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

20

High-throughput

0.536

High

476394

GAN
Gigaxonin

1

12

High-throughput

0.536

High

476398

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

12

High-throughput

0.536

High

476404

TXLNG
Gamma-taxilin

1

20

High-throughput

0.536

High

476407

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

9

High-throughput

0.536

High

476418

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

4

High-throughput

0.536

High

476298

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

10

High-throughput

0.484

High

476330

AMOT
Angiomotin

1

20

High-throughput

0.481

High

131299

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

9

Small-scale

0.479

High

136265

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

141289

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

Small-scale

0.479

High

187260

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

11

High-throughput

0.479

High

209444

SERA
D-3-phosphoglycerate dehydrogenase

1

7

Small-scale

0.479

High

240543

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

271837

OBSL1
Obscurin-like protein 1

1

11

High-throughput

0.479

High

277258

PITX3
Pituitary homeobox 3

1

9

Small-scale

0.479

High

297410

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

High-throughput

0.479

High

302334

RNF8
E3 ubiquitin-protein ligase RNF8

1

15

High-throughput

0.479

High

324438

HEXI1
Protein HEXIM1

1

20

High-throughput

0.479

High

348944

LATS1
Serine/threonine-protein kinase LATS1

1

12

High-throughput

0.479

High

362635

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.479

High

366147

HPT
Haptoglobin

1

2

High-throughput

0.479

High

370979

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

388932

FINC
Fibronectin

1

7

High-throughput

0.479

High

413046

P53
Cellular tumor antigen p53

1

8

Small-scale

0.479

High

442975

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

4

Small-scale

0.479

High

476254

F16P1
Fructose-1,6-bisphosphatase 1

1

6

High-throughput

0.479

High

476255

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

14

High-throughput

0.479

High

476256

ARAF
Serine/threonine-protein kinase A-Raf

1

6

High-throughput

0.479

High

476260

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

476264

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

476268

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.479

High

476272

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

476278

EPS15
Epidermal growth factor receptor substrate 15

1

18

High-throughput

0.479

High

476279

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

476280

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

476283

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.479

High

476284

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

476289

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

476291

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

High-throughput

0.479

High

476292

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

476293

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

476296

ARF1
ADP-ribosylation factor 1

1

6

High-throughput

0.479

High

476297

ARF5
ADP-ribosylation factor 5

1

6

High-throughput

0.479

High

476300

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

476304

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.479

High

476305

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

476306

TRI26
Tripartite motif-containing protein 26

1

13

Small-scale

0.479

High

476311

DX39B
Spliceosome RNA helicase DDX39B

1

20

High-throughput

0.479

High

476314

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

476317

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.479

High

476318

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

18

High-throughput

0.479

High

476322

EZH2
Histone-lysine N-methyltransferase EZH2

1

14

High-throughput

0.479

High

476329

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

476334

OTU1
Ubiquitin thioesterase OTU1

1

9

High-throughput

0.479

High

476337

FBW10
F-box/WD repeat-containing protein 10

1

8

High-throughput

0.479

High

476338

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

476341

PRP8
Pre-mRNA-processing-splicing factor 8

1

11

High-throughput

0.479

High

476342

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

476343

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

476344

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

476345

MEPCE
7SK snRNA methylphosphate capping enzyme

1

15

High-throughput

0.479

High

476352

RBM45
RNA-binding protein 45

1

1

High-throughput

0.479

High

476357

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.479

High

476364

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

476365

HDAC2
Histone deacetylase 2

1

13

High-throughput

0.479

High

476366

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.479

High

476370

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

8

Small-scale

0.479

High

476371

AP2M1
AP-2 complex subunit mu

1

8

High-throughput

0.479

High

476372

MBD6
Methyl-CpG-binding domain protein 6

1

5

High-throughput

0.479

High

476373

RNF31
E3 ubiquitin-protein ligase RNF31

1

17

High-throughput

0.479

High

476378

NECD
Necdin

1

5

High-throughput

0.479

High

476383

ACE2
Angiotensin-converting enzyme 2

1

8

High-throughput

0.479

High

476384

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

8

High-throughput

0.479

High

476385

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

9

Small-scale

0.479

High

476389

RNF38
E3 ubiquitin-protein ligase RNF38

1

9

Small-scale

0.479

High

476391

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

476392

ATG5
Autophagy protein 5

1

5

High-throughput

0.479

High

476397

NMRL1
NmrA-like family domain-containing protein 1

1

2

High-throughput

0.479

High

476399

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

15

High-throughput

0.479

High

476400

ANLN
Anillin

1

12

High-throughput

0.479

High

476405

RNF12
E3 ubiquitin-protein ligase RLIM

1

19

High-throughput

0.479

High

476408

MBD5
Methyl-CpG-binding domain protein 5

1

3

High-throughput

0.479

High

476409

HDAC6
Protein deacetylase HDAC6

1

18

High-throughput

0.479

High

476411

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

476414

FBX2
F-box only protein 2

1

1

Small-scale

0.479

High

476415

FZR1
Fizzy-related protein homolog

1

16

High-throughput

0.479

High

476417

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

18

Small-scale

0.479

High

476419

NEMO
NF-kappa-B essential modulator

1

9

Small-scale

0.479

High

59903

A2BDD9
AMOT protein

1

20

High-throughput

0.470

High

285565

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

322572

FBX21
F-box only protein 21

1

0

Small-scale

0.458

High

327747

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

379196

IGHG1
Immunoglobulin heavy constant gamma 1

1

11

High-throughput

0.445

High

476257

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

476266

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.445

High

476273

BMI1
Polycomb complex protein BMI-1

1

15

High-throughput

0.445

High

476290

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

476303

LG3BP
Galectin-3-binding protein

1

9

High-throughput

0.445

High

476332

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

476359

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

476387

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

476390

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

105164

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

293092

CD123
Translation initiation factor eIF2 assembly protein

1

13

High-throughput

0.437

High

476262

TIMP2
Metalloproteinase inhibitor 2

1

9

High-throughput

0.437

High

476267

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

476285

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

476286

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

476331

EMC4
ER membrane protein complex subunit 4

1

4

High-throughput

0.437

High

476333

RC3H1
Roquin-1

1

12

High-throughput

0.437

High

476368

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

3

High-throughput

0.437

High

476376

DIRA2
GTP-binding protein Di-Ras2

1

3

Small-scale

0.437

High

476388

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.437

High

476396

RC3H2
Roquin-2

1

19

High-throughput

0.437

High

476410

KS6B2
Ribosomal protein S6 kinase beta-2

1

8

High-throughput

0.437

High

476416

AAR2
Protein AAR2 homolog

1

6

High-throughput

0.437

High

897

SIM26
Small integral membrane protein 26

1

5

High-throughput

0.407

High

476269

HEMH
Ferrochelatase, mitochondrial

1

4

High-throughput

0.407

High

476312

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.407

High

476353

SULF2
Extracellular sulfatase Sulf-2

1

11

High-throughput

0.407

High


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Last updated: 11Aug2025