HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: LRC49 (Q8IUZ0)
Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4)
Gene: LRRC49

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_4~LRR_8, LRR_4~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 686
+	Hs
		384823 NTRK1_HUMAN (1-796): 0: 621: 100.00		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	Hs
		265887 NTRK1_HUMAN (1-796): 0: 621: 100.00		LGR5_HUMAN (6-229): 2.15e-21: 101: 20.00
+	Hs
		508286 FGFR1_HUMAN (195-794): 0: 545: 26.34		MFHA1_HUMAN (55-395): 7.73e-40: 159: 18.75
+	Hs
		385751 NTRK1_HUMAN (1-796): 0: 621: 100.00		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		385127 NTRK1_HUMAN (1-796): 0: 621: 100.00		CEP97_HUMAN (24-184): 1.03e-10: 67: 16.13
+	Hs
		507995 FGFR1_HUMAN (195-794): 0: 545: 26.34		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	Hs
		385537 NTRK1_HUMAN (1-796): 0: 621: 100.00		LRC40_HUMAN (71-195): 7.62e-09: 60.8: 18.46
+	Hs
		1083879 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		1081571 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Mm
		546311 NTRK2_MOUSE (12-796): 2.75e-174: 524: 47.32		ERBIN_MOUSE (71-458): 3.37e-36: 148: 19.39
+	Hs
		1049964 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	Hs
		608091 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		607966 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	Hs
		601574 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		508279 FGFR1_HUMAN (195-794): 0: 545: 26.34		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		1083911 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		1081656 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		608203 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		608086 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		LRIQ1_HUMAN (119-237): 1.92e-10: 66.6: 26.89
+	Hs
		601568 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		LRIQ1_HUMAN (119-237): 1.92e-10: 66.6: 26.89