HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	19373254, 25494483, 27182664, 21113135, 18931663, 38803224
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CARD~ubiquitin, ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 618
+	Hs
		476011 UBC_HUMAN (1-685): 0: 846: 100.00		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		475718 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		475639 UBC_HUMAN (1-685): 0: 846: 100.00		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		476171 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC7_HUMAN (299-618): 4.32e-34: 133: 20.94
+	Hs
		476431 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42
+	Hs
		475629 UBC_HUMAN (1-685): 0: 846: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Xl
		1151527 Q7SY79_XENLA (77-685): 0: 744: 99.84		MIB1_XENLA (231-616): 2.89e-51: 192: 16.04
+	Hs
		476162 UBC_HUMAN (1-685): 0: 846: 100.00		MIB2_HUMAN (558-617): 3.21e-10: 65.3: 36.67
+	Mm
		140018 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	At
		1091822 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		MIP1_ARATH (311-616): 1.56e-32: 135: 15.43
+	Hs
		475022 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		923960 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Rn
		88798 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZVH5_RAT (337-617): 1e-37: 147: 14.61
+	Mm
		476824 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		XIAP_MOUSE (20-173): 1.62e-31: 130: 28.66
+	Rn
		1144301 UBC_RAT (1-108): 1.27e-29: 127: 90.74		XIAP_RAT (20-167): 1.35e-30: 127: 27.82
+	Hs
		474998 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		474994 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		171467 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12
+	Mm
		476925 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MIB2_MOUSE (558-617): 3.64e-10: 65.3: 36.67