HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20348096
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 947
+	Hs
		475390 UBC_HUMAN (1-685): 0: 846: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		475345 UBC_HUMAN (1-685): 0: 846: 100.00		KS6B1_HUMAN (341-818): 1.79e-124: 389: 18.20
+	Hs
		116959 UBC_HUMAN (1-685): 0: 846: 100.00		SGK1_HUMAN (354-729): 7.08e-116: 363: 21.19
+	Hs
		475703 UBC_HUMAN (1-685): 0: 846: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		476603 UBC_HUMAN (1-685): 0: 846: 100.00		M3K2_HUMAN (386-626): 1.28e-24: 112: 33.60
+	Hs
		476266 UBC_HUMAN (1-685): 0: 846: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Rn
		88724 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZTD1_RAT (1-947): 0: 772: 84.62
+	Sc
		419769 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		SNF1_YEAST (396-846): 2.96e-117: 374: 18.13
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (399-839): 5.02e-130: 403: 19.29
+	At
		955189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN11_ARATH (399-748): 4.18e-126: 393: 19.78
+	Hs
		681773 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		474936 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT2_HUMAN (286-701): 1.96e-133: 411: 20.32
+	Hs
		474935 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		475012 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		1306392 Q9UFQ0_HUMAN (295-533): 4.21e-87: 274: 99.58		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	At
		1092272 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		M2K2_ARATH (376-647): 6.11e-20: 94.7: 29.43
+	Hs
		924221 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K2_HUMAN (386-626): 1.28e-24: 112: 33.60
+	Hs
		924126 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		475017 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		475158 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14