HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 626
+	Hs
		476603 UBC_HUMAN (1-685): 0: 846: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		475390 UBC_HUMAN (1-685): 0: 846: 100.00		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		475703 UBC_HUMAN (1-685): 0: 846: 100.00		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03
+	Hs
		476663 UBC_HUMAN (1-685): 0: 846: 100.00		M3K4_HUMAN (341-624): 3.69e-51: 193: 39.10
+	Hs
		1306392 Q9UFQ0_HUMAN (295-533): 4.21e-87: 274: 99.58		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		924126 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		475158 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K3_HUMAN (1-626): 0: 606: 100.00
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (361-623): 3.5e-131: 396: 31.70
+	At
		955189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN11_ARATH (361-624): 3.46e-129: 391: 31.58
+	Hs
		924221 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		475248 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Rn
		448410 UBC_RAT (1-108): 1.27e-29: 127: 90.74		KPCD_RAT (22-625): 4.95e-139: 422: 17.43
+	Hs
		681773 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Rn
		1144164 UBC_RAT (1-108): 1.27e-29: 127: 90.74		PAK2_RAT (123-624): 1.71e-125: 382: 23.53
+	Hs
		474936 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40
+	Hs
		474935 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		475017 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03