HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBE2O (Q9C0C9)
(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)
Gene: UBE2O

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	30017913, 27182664, 34642328, 17550899
Identification Methods	enzymatic study, proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1292
+	Hs
		476431 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC6_HUMAN (670-1224): 6.17e-75: 277: 20.03
+	Dm
		477548 UBIQP_DROME (1-610): 0: 752: 99.84		Q9Y165_DROME (701-1106): 6.38e-104: 340: 18.99
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (953-1106): 1.71e-62: 211: 22.29
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (953-1106): 2.59e-62: 210: 21.02
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (953-1106): 1.82e-61: 208: 19.11
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (953-1106): 2.98e-61: 207: 22.93
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (900-1105): 1.81e-60: 207: 16.27
+	Hs
		476388 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2Z_HUMAN (941-1143): 1.12e-57: 205: 29.67
+	Hs
		475504 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E1_HUMAN (927-1105): 1.37e-58: 202: 17.49
+	Hs
		476424 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2T_HUMAN (956-1135): 5.53e-55: 191: 26.52
+	Hs
		475832 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2S_HUMAN (942-1108): 1.64e-49: 177: 27.55
+	Hs
		475552 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2N_HUMAN (956-1103): 1.44e-45: 163: 22.52
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (956-1112): 5.42e-42: 152: 26.75
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (956-1112): 2.98e-41: 150: 27.39
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (953-1106): 1.71e-62: 211: 22.29
+	Dm
		1376599 Q9W418_DROME (229-685): 0: 557: 99.78		Q9Y165_DROME (701-1106): 6.38e-104: 340: 18.99
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (953-1106): 7.82e-62: 209: 21.66
+	Dr
		94560 F1QHN6_DANRE (229-685): 0: 555: 99.78		Q7T3F3_DANRE (956-1103): 4.04e-45: 162: 22.52
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (953-1105): 3.22e-58: 199: 21.80
+	Sc
		410203 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC2_YEAST (956-1112): 4.12e-41: 151: 25.48