HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	38803224, 18636086
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 729
+	Hs
		475745 UBC_HUMAN (1-685): 0: 846: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158377 UBC_HUMAN (1-685): 0: 846: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		167451 UBC_HUMAN (1-685): 0: 846: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		262227 UBC_HUMAN (1-685): 0: 846: 100.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		475222 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TBK1_HUMAN (1-729): 0: 564: 100.00
+	At
		1091646 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		MPK4_ARATH (12-351): 8.93e-120: 365: 16.76
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (8-395): 3.62e-117: 363: 20.05
+	Mm
		477048 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKE_MOUSE (1-714): 5.03e-152: 460: 46.51
+	Mm
		291435 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKB_MOUSE (9-708): 1.02e-140: 433: 19.60
+	Hs
		625332 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Mm
		476818 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKA_MOUSE (9-637): 1.7e-120: 379: 20.94
+	Hs
		397911 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	At
		98421 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RUK_ARATH (13-221): 2.64e-22: 105: 33.18
+	Mm
		250791 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ULK1_MOUSE (13-222): 5.35e-26: 116: 33.64