Protein: NDKM
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)

Gene: NDKM, NME4
Organism: Homo sapiens
Interactions: 194
UniProt ID: O00746

Gene Ontology (top 5):
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143796

NDKA
Nucleoside diphosphate kinase A

6

17

High-throughput

0.954

High

143841

NDK3
Nucleoside diphosphate kinase 3

3

16

High-throughput

0.861

High

143798

NDKB
Nucleoside diphosphate kinase B

3

17

High-throughput

0.849

High

143764

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

16

Small-scale

0.799

High

143951

NDK7
Nucleoside diphosphate kinase homolog 7

2

16

High-throughput

0.783

High

143849

PCH2
Pachytene checkpoint protein 2 homolog

3

5

High-throughput

0.667

High

143800

ITB8
Integrin beta-8

3

2

High-throughput

0.667

High

143836

GRSF1
G-rich sequence factor 1

3

0

Small-scale

0.613

High

143879

HDAC7
Histone deacetylase 7

2

4

High-throughput

0.606

High

143895

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

1

High-throughput

0.606

High

143767

TPP1
Tripeptidyl-peptidase 1

2

0

High-throughput

0.602

High

143770

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.602

High

143821

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

143833

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

143864

CLNK
Cytokine-dependent hematopoietic cell linker

2

2

High-throughput

0.594

High

143844

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

143773

CISY
Citrate synthase, mitochondrial

2

4

High-throughput

0.584

High

143774

MPPB
Mitochondrial-processing peptidase subunit beta

2

1

High-throughput

0.584

High

143835

MPPA
Mitochondrial-processing peptidase subunit alpha

2

1

High-throughput

0.584

High

143808

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

143822

LMO4
LIM domain transcription factor LMO4

2

0

High-throughput

0.580

High

143856

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

0

High-throughput

0.580

High

143873

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.580

High

143932

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.580

High

143874

TSYL6
Testis-specific Y-encoded-like protein 6

2

2

High-throughput

0.574

High

143881

CBPA5
Carboxypeptidase A5

2

2

High-throughput

0.574

High

143812

EFTS
Elongation factor Ts, mitochondrial

2

0

High-throughput

0.559

High

143832

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.559

High

143850

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

143811

HD
Huntingtin

2

1

High-throughput

0.558

High

143768

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.553

High

143797

PSB1
Proteasome subunit beta type-1

2

6

High-throughput

0.553

High

143819

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

3

High-throughput

0.553

High

143823

NTF2
Nuclear transport factor 2

2

3

High-throughput

0.553

High

143831

ZBT16
Zinc finger and BTB domain-containing protein 16

2

1

High-throughput

0.553

High

143851

CCD57
Coiled-coil domain-containing protein 57

2

1

High-throughput

0.553

High

143855

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.553

High

143896

CIB3
Calcium and integrin-binding family member 3

2

2

High-throughput

0.553

High

143902

CIB1
Calcium and integrin-binding protein 1

2

2

High-throughput

0.553

High

143924

CABP5
Calcium-binding protein 5

2

3

High-throughput

0.553

High

143925

CABP2
Calcium-binding protein 2

2

3

High-throughput

0.553

High

143936

ABI2
Abl interactor 2

2

1

High-throughput

0.553

High

143942

NXF1
Nuclear RNA export factor 1

2

1

High-throughput

0.553

High

143872

TENS4
Tensin-4

2

1

High-throughput

0.542

High

143814

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

143805

SYUA
Alpha-synuclein

1

1

High-throughput

0.515

High

143840

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.515

High

143817

TUB
Tubby protein homolog

1

0

High-throughput

0.513

High

143869

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.513

High

143766

TOR1A
Torsin-1A

1

0

High-throughput

0.493

High

143781

HBD
Hemoglobin subunit delta

1

0

High-throughput

0.493

High

143807

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

143880

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

143801

CO8A1
Collagen alpha-1(VIII) chain

1

3

High-throughput

0.489

High

143815

CBPA2
Carboxypeptidase A2

1

2

High-throughput

0.489

High

143948

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.489

High

61357

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

143771

NRDC
Nardilysin

1

3

High-throughput

0.479

High

143775

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

143778

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

143783

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

143789

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

143793

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

143804

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

143806

HSPA9
Stress-70 protein, mitochondrial

1

9

High-throughput

0.479

High

143809

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

143813

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

143816

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

143824

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

143827

CYC
Cytochrome c

1

1

High-throughput

0.479

High

143834

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

143837

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

143838

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.479

High

143843

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.479

High

143845

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

143846

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

143848

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

143853

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.479

High

143854

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

143858

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

143862

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

143863

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

143870

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

143876

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

143882

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

143883

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

5

High-throughput

0.479

High

143884

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

143886

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

143887

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

143888

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

143890

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

143894

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

143898

EFGM
Elongation factor G, mitochondrial

1

5

High-throughput

0.479

High

143899

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

143907

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

143913

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

143916

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

143918

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

143923

NT5D2
5'-nucleotidase domain-containing protein 2

1

1

High-throughput

0.479

High

143930

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.479

High

143931

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

143933

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

143937

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

143943

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

143949

PDIP2
Polymerase delta-interacting protein 2

1

1

High-throughput

0.479

High

143952

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

143780

ANGT
Angiotensinogen

1

1

High-throughput

0.470

High

143782

KLKB1
Plasma kallikrein

1

2

High-throughput

0.470

High

143786

LIPL
Lipoprotein lipase

1

1

High-throughput

0.470

High

143790

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.470

High

143818

ATX1
Ataxin-1

1

1

High-throughput

0.470

High

143908

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

1

High-throughput

0.470

High

66079

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

143769

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

143776

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

143779

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

143785

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

143787

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

143792

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

143795

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.458

High

143810

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

143820

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

143825

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

143828

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

143830

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

143847

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

143852

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.458

High

143857

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

143859

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

143865

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

High-throughput

0.458

High

143878

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

0

High-throughput

0.458

High

143885

ISOC2
Isochorismatase domain-containing protein 2

1

0

High-throughput

0.458

High

143889

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

143891

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

143897

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

143901

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.458

High

143903

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

143904

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

143905

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

143906

TR61B
tRNA

1

0

High-throughput

0.458

High

143909

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.458

High

143910

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

143912

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

143914

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

143915

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

143917

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.458

High

143921

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

143922

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

143926

NGRN
Neugrin

1

0

High-throughput

0.458

High

143927

PPA6
Lysophosphatidic acid phosphatase type 6

1

0

High-throughput

0.458

High

143929

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.458

High

143934

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

143940

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

143945

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.458

High

143950

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

143953

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

143799

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

143765

SOCS3
Suppressor of cytokine signaling 3

1

2

High-throughput

0.439

High

143791

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.439

High

104821

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

143788

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.437

High

143803

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.437

High

143826

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

143829

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.437

High

143860

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

143861

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.437

High

143867

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

143893

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

143939

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

143784

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.407

High

143794

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.328

High

143868

TMM25
Transmembrane protein 25

2

0

High-throughput

0.328

High

143941

DKK3
Dickkopf-related protein 3

2

0

High-throughput

0.328

High

143877

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

0

High-throughput

0.324

High

143772

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

143839

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

143866

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

143871

CF206
Cilia- and flagella-associated protein 206

2

0

High-throughput

0.316

High

143911

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.316

High

143920

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

143935

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.316

High

143938

SPG21
Maspardin

2

0

High-throughput

0.316

High

143944

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.316

High

143802

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

143842

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

143875

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

0

High-throughput

0.279

Low

143900

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

143928

MMP26
Matrix metalloproteinase-26

1

0

High-throughput

0.279

Low

143947

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.268

Low

143919

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

0

High-throughput

0.265

Low

143777

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.251

Low

143946

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

143892

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025