HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	28190767, 29576527, 28935764, 33141564, 34326324, 34642328, 36114200, 38803224, 16196087, 25702870, 27066941, 28338014, 34761751, 22284438
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin, UCH_C~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 329
+	Hs
		475307 UBC_HUMAN (1-685): 0: 846: 100.00		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Hs
		456475 UBC_HUMAN (1-685): 0: 846: 100.00		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		476130 UBC_HUMAN (1-685): 0: 846: 100.00		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Mm
		477056 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UCHL5_MOUSE (1-329): 7.44e-176: 491: 96.96
+	Hs
		398154 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Sc
		477215 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBL1_YEAST (1-226): 3.54e-61: 196: 24.58
+	Mm
		477030 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UCHL3_MOUSE (4-226): 2.22e-84: 256: 26.61
+	Hs
		456536 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Mm
		476730 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UCHL4_MOUSE (4-226): 6.61e-81: 247: 26.27
+	Hs
		474910 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Hs
		548107 Q5U5U6_HUMAN (1-77): 7.83e-26: 108: 98.70		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Mm
		477047 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UCHL1_MOUSE (10-226): 1.44e-72: 225: 22.67
+	Rn
		962731 UBC_RAT (1-108): 1.27e-29: 127: 90.74		UCHL1_RAT (10-226): 1.44e-72: 225: 22.67
+	Hs
		456474 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		924096 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29