HitPredict

Interactor 1: TPC2B (P0DI82)
Trafficking protein particle complex subunit 2B (MBP-1-interacting protein 2A) (MIP-2A)
Gene: TRAPPC2B

Interactor 2: TPC3L (Q5T215)
Trafficking protein particle complex subunit 3-like protein (TRAPPC3-like protein) (BET3-like protein)
Gene: TRAPPC3L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21525244
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Sedlin_N~TRAPP
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0030008 - TRAPP complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 181
+	Hs
		208704 TPC2A_HUMAN (1-140): 8.79e-67: 200: 100.00		TPPC3_HUMAN (1-181): 2.98e-105: 301: 61.88
+	Hs
		208705 TPC2B_HUMAN (1-140): 8.79e-67: 200: 100.00		TPPC3_HUMAN (1-181): 2.98e-105: 301: 61.88
+	Mm
		222946 TPPC2_MOUSE (1-140): 6.68e-67: 200: 97.86		TPPC3_MOUSE (1-181): 5.69e-105: 300: 61.33
+	Dm
		1373754 TPPC2_DROME (3-140): 6.6e-59: 180: 57.97		Q9VSY8_DROME (1-181): 1.29e-89: 261: 46.41
+	Hs
		208753 TPC2L_HUMAN (4-133): 2.81e-41: 135: 20.42		TPPC3_HUMAN (1-181): 2.98e-105: 301: 61.88
+	Hs
		1132769 TPC2L_HUMAN (4-133): 2.81e-41: 135: 20.42		TPC3L_HUMAN (1-181): 8.84e-103: 294: 100.00
+	Sc
		733728 TRS20_YEAST (6-138): 6.12e-48: 154: 33.53		BET3_YEAST (10-181): 1.3e-86: 254: 46.82
+	Dm
		53204 A1Z8I0_DROME (4-133): 2.61e-42: 138: 25.71		Q9VSY8_DROME (1-181): 1.29e-89: 261: 46.41
+	Dm
		87961 D3DMJ4_DROME (4-133): 3.6e-42: 138: 25.71		Q9VSY8_DROME (1-181): 1.29e-89: 261: 46.41
+	Ce
		137381 TPPC2_CAEEL (5-138): 1.19e-55: 172: 55.88		TPPC3_CAEEL (8-181): 7.86e-68: 206: 39.55