HitPredict

Interactor 1: DL (P10041)
Neurogenic locus protein delta
Gene: Delta

Interactor 2: Q9VJ14 (Q9VJ14)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Gene: mib2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	15710747
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007219 - Notch signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 833 Dm			1 1049
+	Hs
		804293 NOTC1_HUMAN (380-824): 1.79e-39: 160: 18.82		ANR44_HUMAN (159-796): 9.68e-104: 350: 15.23
+	Hs
		944122 JAG1_HUMAN (28-713): 1.66e-52: 200: 19.78		MIB1_HUMAN (2-579): 5.29e-74: 266: 15.37
+	Mm
		1193398 JAG1_MOUSE (28-713): 1.13e-52: 201: 19.92		MIB1_MOUSE (2-570): 7.41e-72: 260: 16.04
+	Dm
		485032 DL_DROME (1-833): 6.36e-113: 365: 100.00		MIB_DROME (1-76): 1.14e-15: 84.2: 43.42
+	Hs
		980449 NOTC2_HUMAN (19-437): 1.87e-15: 83.5: 11.63		ANR44_HUMAN (159-796): 9.68e-104: 350: 15.23
+	Hs
		1237561 NOTC3_HUMAN (25-424): 4.25e-14: 78.9: 12.14		ANR44_HUMAN (159-796): 9.68e-104: 350: 15.23
+	Mm
		1193399 JAG2_MOUSE (12-523): 6.59e-36: 148: 21.29		MIB1_MOUSE (2-570): 7.41e-72: 260: 16.04
+	Hs
		946786 CRUM1_HUMAN (168-332): 7.68e-20: 97.6: 20.53		MIB1_HUMAN (2-579): 5.29e-74: 266: 15.37
+	Mm
		291769 DLL3_MOUSE (162-346): 3.59e-19: 94.2: 24.64		MIB1_MOUSE (2-570): 7.41e-72: 260: 16.04
+	Hs
		132263 DLL1_HUMAN (478-832): 4.78e-13: 75: 11.45		MIB1_HUMAN (2-579): 5.29e-74: 266: 15.37
+	Dr
		1193380 DLLC_DANRE (502-826): 1.76e-12: 73.1: 12.77		MIB1_DANRE (2-570): 8.01e-73: 263: 16.57
+	Mm
		1142610 DLL1_MOUSE (479-832): 2.2e-12: 72.7: 11.77		MIB1_MOUSE (2-570): 7.41e-72: 260: 16.04
+	Hs
		946074 DLK1_HUMAN (422-565): 6.28e-13: 73.2: 32.90		KDIS_HUMAN (231-643): 4.87e-68: 252: 18.03
+	Dr
		47661 DLLC_DANRE (502-826): 1.76e-12: 73.1: 12.77		A0AR23_DANRE (538-1049): 6.73e-58: 219: 22.44
+	Dr
		47638 A1L1P2_DANRE (554-824): 3.42e-11: 68.9: 9.82		A0AR23_DANRE (538-1049): 6.73e-58: 219: 22.44
+	Hs
		1284699 JAG2_HUMAN (479-831): 1.37e-13: 77: 12.68		MIB2_HUMAN (324-1049): 2.2e-54: 207: 19.71
+	Dm
		575654 SERR_DROME (64-716): 2.91e-33: 140: 16.71		MIB_DROME (1-76): 1.14e-15: 84.2: 43.42
+	Hs
		166914 NOTC2_HUMAN (19-437): 1.87e-15: 83.5: 11.63		ANR28_HUMAN (760-1045): 1.91e-14: 80.4: 8.25
+	Dm
		706662 FAT_DROME (14-109): 5.54e-13: 75.4: 14.95		MIB_DROME (1-76): 1.14e-15: 84.2: 43.42
+	Hs
		167042 NOTC3_HUMAN (25-424): 4.25e-14: 78.9: 12.14		ANR28_HUMAN (760-1045): 1.91e-14: 80.4: 8.25