Interactor 1: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Interactor 2: IF4F2 (P39936)
Eukaryotic initiation factor 4F subunit p130 (eIF-4F p130) (eIF4F p130) (Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2) (eIF4G2) (mRNA cap-binding protein complex subunit p130)
Gene: TIF4632

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 12861028, 11805837, 10409745, 37968396, 16554755, 23184954
Identification Methods affinity chromatography technology, surface plasmon resonance, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~MIF4G, Helicase_C~MIF4G
Common GO terms GO:0003743 - translation initiation factor activity
GO:0005840 - ribosome
GO:0006413 - translational initiation
GO:0006446 - regulation of translational initiation
GO:0010494 - cytoplasmic stress granule
and 2 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 395
Sc

1 914
+ Mm
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Sc
+ Hs
+ Hs
+ Dm
+ At
+ Hs
+ Sc
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024