HitPredict

Interactor 1: IL8 (P10145)
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Gene: CXCL8

Interactor 2: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	17375198, 18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 707
+	Hs
		540419 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		364037 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		540414 CXCL2_HUMAN (23-99): 1.44e-24: 90.5: 40.26		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		540420 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		486190 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		MMP13_HUMAN (1-277): 5.97e-98: 311: 35.15
+	Hs
		486188 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		372724 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		764724 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		372733 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		364043 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		448989 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		587770 CXCL2_HUMAN (23-99): 1.44e-24: 90.5: 40.26		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Mm
		714630 CXCL5_MOUSE (7-97): 1.46e-26: 96.7: 35.87		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Hs
		364034 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		372731 CXCL2_HUMAN (23-99): 1.44e-24: 90.5: 40.26		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		486182 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		MMP8_HUMAN (35-295): 3.17e-81: 267: 32.01
+	Hs
		372737 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Mm
		500671 CXCL2_MOUSE (16-99): 7.01e-26: 94: 40.48		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Mm
		714631 CXCL3_MOUSE (16-99): 1.6e-24: 90.5: 39.29		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Hs
		612139 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		MMP8_HUMAN (35-295): 3.17e-81: 267: 32.01