Protein: SMC4
Structural maintenance of chromosomes protein 4

Gene: SMC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 45
UniProt ID: Q12267

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000796 - condensin complex
GO:0003682 - chromatin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

808614

SMC2
Structural maintenance of chromosomes protein 2

6

15

Small-scale

0.950

High

794854

CND2
Condensin complex subunit 2

6

7

Small-scale

0.938

High

1053935

CND1
Condensin complex subunit 1

5

18

Small-scale

0.916

High

864388

SMC3
Structural maintenance of chromosomes protein 3

2

19

Small-scale

0.775

High

1056512

CND3
Condensin complex subunit 3

7

10

Small-scale

0.742

High

364815

CDK1
Cyclin-dependent kinase 1

3

11

Small-scale

0.670

High

1064295

SGO1
Shugoshin

3

3

Small-scale

0.646

High

747769

SMC1
Structural maintenance of chromosomes protein 1

1

18

Small-scale

0.618

High

866084

NNF1
Kinetochore-associated protein NNF1

2

1

High-throughput

0.595

High

678909

CSM1
Monopolin complex subunit CSM1

2

1

Small-scale

0.584

High

459183

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.536

High

1060844

PML1
Pre-mRNA leakage protein 1

1

0

High-throughput

0.513

High

755320

NUF2
Kinetochore protein NUF2

1

4

High-throughput

0.508

High

386916

TBB
Tubulin beta chain

1

5

Small-scale

0.501

High

486356

TBA1
Tubulin alpha-1 chain

1

10

Small-scale

0.501

High

792464

BOI1
BEM1-interacting protein 1

1

8

High-throughput

0.501

High

1026864

CDC14
Tyrosine-protein phosphatase CDC14

1

9

Small-scale

0.501

High

853611

SCD6
Protein SCD6

1

1

Small-scale

0.481

High

461030

MOD5
tRNA dimethylallyltransferase

1

1

Small-scale

0.479

High

647858

RFA1
Replication factor A protein 1

1

4

Small-scale

0.479

High

708544

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735805

TFC1
Transcription factor tau 95 kDa subunit

1

1

Small-scale

0.479

High

797354

INCE
Inner centromere protein SLI15

1

1

Small-scale

0.479

High

826939

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

865906

BIR1
Chromosomal passenger complex protein BIR1

1

1

Small-scale

0.479

High

925142

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

1084568

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

1084699

SMT3
Ubiquitin-like protein SMT3

1

7

High-throughput

0.479

High

1084700

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

918779

NNF2
Protein NNF2

1

1

High-throughput

0.464

High

393530

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

546764

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

742689

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

820132

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

865974

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.445

High

924077

JJJ1
J protein JJJ1

1

7

High-throughput

0.445

High

924524

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

1060424

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.445

High

924781

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

405156

LEU3
3-isopropylmalate dehydrogenase

1

1

Small-scale

0.437

High

522359

MPPB
Mitochondrial-processing peptidase subunit beta

2

0

High-throughput

0.307

High

511971

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.249

Low

688829

RFA3
Replication factor A protein 3

1

0

Small-scale

0.249

Low

781479

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

917782

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025