HitPredict

Interactor 1: IL8 (P10145)
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Gene: CXCL8

Interactor 2: ACKR1 (Q16570)
Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
Gene: ACKR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	9195930, 7592830, 10206993, 8558064, 8132497, 15720550
Identification Methods	biochemical, affinity chromatography technology, competition binding, saturation binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 336
+	Hs
		449000 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		ACKR1_HUMAN (1-336): 6.26e-100: 299: 100.00
+	Hs
		486185 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		486184 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		625748 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		364042 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		448988 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		587767 CXCL2_HUMAN (23-99): 1.44e-24: 90.5: 40.26		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625758 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		587786 CXCL3_HUMAN (30-99): 7.58e-24: 89: 41.43		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625736 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		364041 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		448987 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		625737 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		217747 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		CXCR5_HUMAN (55-319): 3.59e-71: 227: 17.75
+	Hs
		217753 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		ACKR4_HUMAN (20-332): 4.02e-65: 210: 11.75
+	Mm
		500672 CXCL2_MOUSE (16-99): 7.01e-26: 94: 40.48		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Mm
		522397 GROA_MOUSE (26-95): 1.26e-23: 87.8: 50.00		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Hs
		217751 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49
+	Mm
		291525 CXCL9_MOUSE (4-91): 4.77e-25: 92.5: 32.58		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75
+	Mm
		291524 CXL10_MOUSE (1-95): 2.97e-24: 89.8: 22.92		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75