HitPredict

Interactor 1: MYB (P10242)
Transcriptional activator Myb (Proto-oncogene c-Myb)
Gene: MYB

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.937

The method score is based on:

Property Details
Experiments 35140242, 11585920, 10656693, 25740244, 29954426, 15691758
Identification Methods proximity labelling technology, pull down, enzymatic study, affinity chromatography technology
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains KIX~LMSTEN, Myb_DNA-binding~ZZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 2 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 640
Hs

1 2414
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024