HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	35785414, 20661446, 21730179
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030521 - androgen receptor signaling pathway GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 459
+	Hs
		487405 ANDR_HUMAN (1-920): 0: 966: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		487372 ANDR_HUMAN (1-920): 0: 966: 100.00		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		487173 ANDR_HUMAN (1-920): 0: 966: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		369442 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		369544 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		377261 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Mm
		415156 GCR_MOUSE (444-920): 1.46e-113: 368: 40.24		FKBP4_MOUSE (1-459): 2.03e-148: 432: 89.76
+	Hs
		437634 MCR_HUMAN (401-920): 3.98e-106: 353: 38.18		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		377301 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Mm
		415159 GCR_MOUSE (444-920): 1.46e-113: 368: 40.24		FKBP5_MOUSE (1-451): 1.47e-136: 402: 53.66
+	Hs
		685005 Q9BZG7_HUMAN (1-539): 0: 567: 99.08		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		369479 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		370658 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		FKBPL_HUMAN (135-415): 6.34e-49: 172: 26.15
+	Hs
		377276 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		369598 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		437638 MCR_HUMAN (401-920): 3.98e-106: 353: 38.18		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		118677 MCR_HUMAN (401-920): 3.98e-106: 353: 38.18		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		1053109 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		369072 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		377132 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51