HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	11416139, 33640491
Identification Methods	two hybrid, affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 920 Hs			1 197
+	Hs
		487357 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		487355 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		487356 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		369456 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		369457 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		914640 ERR3_HUMAN (467-904): 1.39e-116: 365: 21.54		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		377264 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		782522 HNF4A_HUMAN (536-906): 1e-104: 335: 22.85		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		782527 HNF4A_HUMAN (536-906): 1e-104: 335: 22.85		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00