HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	11117529
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 628
+	Hs
		277899 ANDR_HUMAN (1-920): 0: 966: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278213 ANDR_HUMAN (1-920): 0: 966: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		487590 ANDR_HUMAN (1-920): 0: 966: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		370843 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		487832 ANDR_HUMAN (1-920): 0: 966: 100.00		ZMIZ1_HUMAN (79-422): 1.82e-84: 287: 24.93
+	Hs
		1270069 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		487597 ANDR_HUMAN (1-920): 0: 966: 100.00		ZMIZ2_HUMAN (81-619): 2.53e-79: 271: 20.46
+	Hs
		414536 PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		611538 NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		277875 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277876 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278138 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277885 PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277936 NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278206 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		277974 HNF4A_HUMAN (536-906): 1e-104: 335: 22.85		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278207 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278312 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278210 PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278228 NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71		PIAS2_HUMAN (1-550): 0: 651: 59.00