Protein: UN45A
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)

Gene: UN45A, UNC45A
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q9H3U1

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0007517 - muscle organ development
GO:0016607 - nuclear speck

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461928

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.854

High

468798

HS90B
Heat shock protein HSP 90-beta

2

20

Small-scale

0.768

High

1393561

DIRA2
GTP-binding protein Di-Ras2

2

2

High-throughput

0.700

High

876996

KC1A
Casein kinase I isoform alpha

4

14

High-throughput

0.699

High

1153738

TOM34
Mitochondrial import receptor subunit TOM34

1

20

High-throughput

0.691

High

123831

MYO1C
Unconventional myosin-Ic

3

6

High-throughput

0.675

High

1253937

FA83H
Protein FAM83H

3

2

High-throughput

0.671

High

74062

MYO9A
Unconventional myosin-IXa

3

12

High-throughput

0.650

High

373137

MYC
Myc proto-oncogene protein

3

14

High-throughput

0.640

High

396933

ESR1
Estrogen receptor

3

20

High-throughput

0.640

High

1332583

MARHA
Probable E3 ubiquitin-protein ligase MARCHF10

4

2

High-throughput

0.637

High

894162

MEOX2
Homeobox protein MOX-2

2

2

High-throughput

0.633

High

171579

S27A2
Long-chain fatty acid transport protein 2

2

11

High-throughput

0.628

High

1025635

CDK17
Cyclin-dependent kinase 17

2

8

High-throughput

0.628

High

1091713

MYO1E
Unconventional myosin-Ie

2

10

High-throughput

0.628

High

1277784

MYH14
Myosin-14

2

10

High-throughput

0.628

High

1432947

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

16

High-throughput

0.628

High

1328123

TTC9C
Tetratricopeptide repeat protein 9C

1

19

High-throughput

0.618

High

451071

LDHB
L-lactate dehydrogenase B chain

1

6

High-throughput

0.618

High

731614

STIP1
Stress-induced-phosphoprotein 1

1

19

High-throughput

0.618

High

1289624

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.618

High

893738

MEOX1
Homeobox protein MOX-1

2

2

High-throughput

0.606

High

564360

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.601

High

650956

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

12

High-throughput

0.601

High

831420

CCNF
Cyclin-F

2

7

High-throughput

0.601

High

401470

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

17

High-throughput

0.584

High

1110076

HDAC1
Histone deacetylase 1

2

8

High-throughput

0.584

High

1094479

IFT88
Intraflagellar transport protein 88 homolog

1

17

High-throughput

0.575

High

959655

MAX
Protein max

2

10

High-throughput

0.573

High

166415

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

2

High-throughput

0.552

High

220017

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

221881

CHM2A
Charged multivesicular body protein 2a

1

2

High-throughput

0.536

High

322996

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

7

High-throughput

0.536

High

773017

MYH9
Myosin-9

1

10

High-throughput

0.536

High

866823

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

867418

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

877228

KC1D
Casein kinase I isoform delta

1

18

High-throughput

0.536

High

885893

KC1E
Casein kinase I isoform epsilon

1

20

High-throughput

0.536

High

905677

IRAK1
Interleukin-1 receptor-associated kinase 1

1

5

High-throughput

0.536

High

1111266

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1158538

CDC37
Hsp90 co-chaperone Cdc37

1

12

High-throughput

0.536

High

1361087

MYO3B
Myosin-IIIb

1

11

High-throughput

0.536

High

1381067

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

1

High-throughput

0.536

High

1392665

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.536

High

1404395

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1405243

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

High-throughput

0.536

High

1432930

CHM1A
Charged multivesicular body protein 1a

1

3

High-throughput

0.536

High

1432940

STK26
Serine/threonine-protein kinase 26

1

20

High-throughput

0.536

High

1432946

PARP2
Poly [ADP-ribose] polymerase 2

1

5

High-throughput

0.536

High

1432949

ALK
ALK tyrosine kinase receptor

2

17

High-throughput

0.533

High

1101190

CLN3
Battenin

1

0

High-throughput

0.513

High

1329353

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

0

High-throughput

0.513

High

1398539

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.513

High

1432953

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

181940

SMAD9
Mothers against decapentaplegic homolog 9

1

6

High-throughput

0.508

High

854292

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.489

High

1142176

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1358776

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

4

High-throughput

0.489

High

1395605

BT3L4
Transcription factor BTF3 homolog 4

1

4

High-throughput

0.489

High

1400389

PUS7
Pseudouridylate synthase 7 homolog

1

1

High-throughput

0.489

High

386229

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.481

High

950003

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.481

High

1361157

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

129423

MEN1
Menin

1

2

High-throughput

0.479

High

184319

NPHP1
Nephrocystin-1

1

2

High-throughput

0.479

High

242913

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

247428

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

14

High-throughput

0.479

High

277406

TP4A3
Protein tyrosine phosphatase type IVA 3

1

13

High-throughput

0.479

High

290150

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

294325

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

342036

CEP43
Centrosomal protein 43

1

2

High-throughput

0.479

High

346322

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

13

High-throughput

0.479

High

409082

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

8

High-throughput

0.479

High

440207

LCK
Tyrosine-protein kinase Lck

1

10

High-throughput

0.479

High

446044

ENOA
Alpha-enolase

1

5

High-throughput

0.479

High

556341

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

637953

NF1
Neurofibromin

1

4

High-throughput

0.479

High

643067

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.479

High

648669

FGFR4
Fibroblast growth factor receptor 4

1

17

High-throughput

0.479

High

650414

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.479

High

705726

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

2

High-throughput

0.479

High

749136

RL9
Large ribosomal subunit protein uL6

1

3

High-throughput

0.479

High

777767

VGFR3
Vascular endothelial growth factor receptor 3

1

7

High-throughput

0.479

High

862456

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

939970

TPTE
Putative tyrosine-protein phosphatase TPTE

1

12

High-throughput

0.479

High

971076

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.479

High

985336

RL10A
Large ribosomal subunit protein uL1

1

4

High-throughput

0.479

High

997133

TBA4A
Tubulin alpha-4A chain

1

16

High-throughput

0.479

High

1024840

VIGLN
Vigilin

1

12

High-throughput

0.479

High

1049776

1433F
14-3-3 protein eta

1

19

High-throughput

0.479

High

1094626

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

High-throughput

0.479

High

1104257

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

19

High-throughput

0.479

High

1104484

ILK
Scaffold protein ILK

1

13

High-throughput

0.479

High

1114286

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1121336

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.479

High

1138054

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

1138629

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1140850

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1149371

STIL
SCL-interrupting locus protein

1

3

High-throughput

0.479

High

1161395

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

High-throughput

0.479

High

1163901

DUS7
Dual specificity protein phosphatase 7

1

7

High-throughput

0.479

High

1178011

MOONR
Protein moonraker

1

2

High-throughput

0.479

High

1178373

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1210989

CE170
Centrosomal protein of 170 kDa

1

8

High-throughput

0.479

High

1215508

CE162
Centrosomal protein of 162 kDa

1

14

High-throughput

0.479

High

1238477

ZN746
Zinc finger protein 746

1

7

High-throughput

0.479

High

1248195

SAS6
Spindle assembly abnormal protein 6 homolog

1

9

High-throughput

0.479

High

1251112

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

11

High-throughput

0.479

High

1255520

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1256590

CE128
Centrosomal protein of 128 kDa

1

10

High-throughput

0.479

High

1280495

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.479

High

1286378

NEK8
Serine/threonine-protein kinase Nek8

1

15

High-throughput

0.479

High

1288500

LBN
Limbin

1

3

High-throughput

0.479

High

1323076

AHI1
Jouberin

1

20

High-throughput

0.479

High

1324079

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.479

High

1327597

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

1331560

CE120
Centrosomal protein of 120 kDa

1

12

High-throughput

0.479

High

1334173

POC1A
POC1 centriolar protein homolog A

1

16

High-throughput

0.479

High

1334906

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1341022

THOC2
THO complex subunit 2

1

16

High-throughput

0.479

High

1349433

POC1B
POC1 centriolar protein homolog B

1

16

High-throughput

0.479

High

1349763

FBX25
F-box only protein 25

1

4

High-throughput

0.479

High

1352750

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1353141

FBF1
Fas-binding factor 1

1

13

High-throughput

0.479

High

1363845

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1364592

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

1366562

AKAP1
A-kinase anchor protein 1, mitochondrial

1

8

High-throughput

0.479

High

1369262

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

11

High-throughput

0.479

High

1380161

FBXW7
F-box/WD repeat-containing protein 7

1

18

High-throughput

0.479

High

1380656

FBX32
F-box only protein 32

1

4

High-throughput

0.479

High

1385391

ARMC5
Armadillo repeat-containing protein 5

1

7

High-throughput

0.479

High

1396188

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

9

High-throughput

0.479

High

1397424

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1399094

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.479

High

1403071

CEP89
Centrosomal protein of 89 kDa

1

17

High-throughput

0.479

High

1415833

NUP85
Nuclear pore complex protein Nup85

1

1

High-throughput

0.479

High

1428350

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

1432924

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

1432925

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.479

High

1432929

CPAP
Centrosomal P4.1-associated protein

1

11

High-throughput

0.479

High

1432931

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

1432932

ANLN
Anillin

1

2

High-throughput

0.479

High

1432933

TLR9
Toll-like receptor 9

1

6

Small-scale

0.479

High

1432934

DUS22
Dual specificity protein phosphatase 22

1

4

High-throughput

0.479

High

1432937

DJC11
DnaJ homolog subfamily C member 11

1

20

High-throughput

0.479

High

1432939

MKS1
Tectonic-like complex member MKS1

1

1

High-throughput

0.479

High

1432942

WRP73
WD repeat-containing protein WRAP73

1

13

High-throughput

0.479

High

1432943

HDAC6
Protein deacetylase HDAC6

1

11

High-throughput

0.479

High

1432944

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1432945

TES
Testin

1

1

High-throughput

0.479

High

1432950

DTX4
E3 ubiquitin-protein ligase DTX4

1

5

Small-scale

0.479

High

1432954

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.479

High

1194585

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

1232574

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

213245

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

228510

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.458

High

1161802

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

1162333

CEGT
Ceramide glucosyltransferase

1

0

High-throughput

0.458

High

1246985

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1390536

CDCA5
Sororin

1

0

High-throughput

0.458

High

1397109

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1432941

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.458

High

1432952

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

1432955

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.458

High

169141

ML12B
Myosin regulatory light chain 12B

1

2

High-throughput

0.445

High

397982

ANGI
Angiogenin

1

2

High-throughput

0.445

High

765887

BMI1
Polycomb complex protein BMI-1

1

8

High-throughput

0.445

High

774619

BASI
Basigin

1

8

High-throughput

0.445

High

886133

CXCR3
C-X-C chemokine receptor type 3

1

2

High-throughput

0.445

High

1209653

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

19

High-throughput

0.445

High

1234951

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1239297

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

1430925

NXF5
Nuclear RNA export factor 5

1

2

High-throughput

0.445

High

1432926

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

1432935

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.445

High

246945

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.437

High

260448

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.437

High

352547

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

412606

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

589672

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

595869

H13
Histone H1.3

1

2

High-throughput

0.437

High

696490

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

711941

LTK
Leukocyte tyrosine kinase receptor

1

18

High-throughput

0.437

High

769163

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

897973

CDK9
Cyclin-dependent kinase 9

1

19

High-throughput

0.437

High

1049201

RON
Macrophage-stimulating protein receptor

1

14

High-throughput

0.437

High

1096815

RFA4
Replication protein A 30 kDa subunit

1

12

High-throughput

0.437

High

1229081

RNF43
E3 ubiquitin-protein ligase RNF43

1

10

High-throughput

0.437

High

1249209

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1250198

LRC31
Leucine-rich repeat-containing protein 31

1

13

High-throughput

0.437

High

1272674

DET1
DET1 homolog

1

3

High-throughput

0.437

High

1276781

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1326340

NIN
Ninein

1

12

High-throughput

0.437

High

1327191

FBXL6
F-box/LRR-repeat protein 6

1

14

High-throughput

0.437

High

1330607

PLD5
Inactive phospholipase D5

1

2

High-throughput

0.437

High

1366835

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

2

High-throughput

0.437

High

1386364

FAF2
FAS-associated factor 2

1

5

High-throughput

0.437

High

1411495

OVOL2
Transcription factor Ovo-like 2

1

10

Small-scale

0.437

High

1432927

BRF2
Transcription factor IIIB 50 kDa subunit

1

3

High-throughput

0.437

High

1432938

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

8

High-throughput

0.437

High

1432948

RCOR1
REST corepressor 1

1

6

High-throughput

0.437

High

1432956

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

6

High-throughput

0.437

High

248944

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

1432928

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.426

High

50122

S22AN
Solute carrier family 22 member 23

1

2

High-throughput

0.407

High

344319

PTBP3
Polypyrimidine tract-binding protein 3

1

10

High-throughput

0.407

High

754099

CD80
T-lymphocyte activation antigen CD80

1

9

High-throughput

0.407

High

1412066

S39A3
Zinc transporter ZIP3

1

3

High-throughput

0.407

High

1432951

S27A6
Long-chain fatty acid transport protein 6

1

11

High-throughput

0.407

High

1381378

TEKT1
Tektin-1

2

0

High-throughput

0.316

High

1410209

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

1432936

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

576682

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

1027180

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1325197

HROB
Homologous recombination OB-fold protein

1

0

Small-scale

0.249

Low

1398558

TIGD1
Tigger transposable element-derived protein 1

1

0

High-throughput

0.249

Low

1127

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

117224

SIM22
Small integral membrane protein 22

1

0

Small-scale

0.232

Low

652250

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.232

Low

1292373

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025