HitPredict

Interactor 1: RARA (P10276)
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
Gene: RARA

Interactor 2: RXRA (P19793)
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
Gene: RXRA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 21478865, 7705655, 16224062, 22539306, 12052862, 9121466, 14521715, 31700049, 1314167, 15171703, 15528208, 9415406, 15604093, 9582446, 21988832, 7760852, 16769902, 25303530, 19345331, 10698945
Identification Methods x-ray crystallography, two hybrid, pull down, affinity chromatography technology, biochemical, far western blotting, small angle neutron scattering, genetic interference, cosedimentation in solution, x ray scattering and 1 others

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Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 19 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Last updated: 15 Jul 2024