HitPredict

Interactor 1: IFIT1 (P09914)
Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1)
Gene: IFIT1

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21642987
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045070 - positive regulation of viral genome replication
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 478 Hs			1 636
+	Hs
		488175 IFIT1_HUMAN (1-478): 2.34e-93: 292: 100.00		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		488094 IFIT2_HUMAN (3-465): 4.14e-67: 224: 44.75		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Hs
		488118 IFIT2_HUMAN (3-465): 4.14e-67: 224: 44.75		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		185388 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Mm
		710988 CTR9_MOUSE (40-449): 1.15e-14: 78.7: 13.05		PABP1_MOUSE (1-636): 0: 570: 99.69
+	Hs
		166752 IFIT3_HUMAN (217-476): 1.57e-12: 71.4: 12.50		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Hs
		185658 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		166781 IFIT3_HUMAN (217-476): 1.57e-12: 71.4: 12.50		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		488151 IFIT1_HUMAN (1-478): 2.34e-93: 292: 100.00		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33
+	Sc
		403333 CYC8_YEAST (2-389): 3.42e-37: 147: 9.34		PABP_YEAST (2-289): 9.7e-65: 225: 30.82
+	Sc
		403503 TOM71_YEAST (202-475): 8.29e-13: 72.5: 15.33		PABP_YEAST (2-289): 9.7e-65: 225: 30.82
+	Sc
		403476 CDC27_YEAST (324-477): 1.2e-09: 62.6: 16.15		PABP_YEAST (2-289): 9.7e-65: 225: 30.82
+	Hs
		185418 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33
+	Hs
		166757 IFIT3_HUMAN (217-476): 1.57e-12: 71.4: 12.50		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33