HitPredict

Interactor 1: METK (P0A817)
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)
Gene: METK

Interactor 2: METK (P0A817)
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)
Gene: METK

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 8611562, 16858726
Identification Methods x-ray crystallography, blue native page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains S-AdoMet_synt_C~S-AdoMet_synt_C, S-AdoMet_synt_C~S-AdoMet_synt_M, S-AdoMet_synt_C~S-AdoMet_synt_N, S-AdoMet_synt_M~S-AdoMet_synt_M, S-AdoMet_synt_M~S-AdoMet_synt_N, S-AdoMet_synt_N~S-AdoMet_synt_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
and 3 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 384
Ec

1 384
+ Hs
+ Hs
+ Hs
+ Rn
+ Zm
+ Ce
+ Sc
+ Ce
+ Sc
+ Sp
+ Sc
+ Ce
+ Ce
+ Dm
+ Pf

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Last updated: 11Aug2025