Protein: METK2
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)

Gene: METK2, MAT2A
Organism: Homo sapiens
Interactions: 165
UniProt ID: P31153

Gene Ontology (top 5):
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

724813

MAT2B
Methionine adenosyltransferase 2 subunit beta

8

1

Small-scale

0.969

High

724741

METK1
S-adenosylmethionine synthase isoform type-1

6

16

High-throughput

0.944

High

724714

METK2
S-adenosylmethionine synthase isoform type-2

4

15

Small-scale

0.898

High

240862

PRKN
E3 ubiquitin-protein ligase parkin

5

2

High-throughput

0.709

High

724757

DUS6
Dual specificity protein phosphatase 6

3

1

High-throughput

0.633

High

724747

CUL3
Cullin-3

2

0

Small-scale

0.612

High

724786

CSN5
COP9 signalosome complex subunit 5

2

2

High-throughput

0.611

High

724756

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

222753

PRC1
Protein regulator of cytokinesis 1

2

0

High-throughput

0.580

High

563279

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

439968

LCK
Tyrosine-protein kinase Lck

2

2

High-throughput

0.571

High

440399

FYN
Tyrosine-protein kinase Fyn

2

2

High-throughput

0.571

High

724748

PTK6
Protein-tyrosine kinase 6

2

2

High-throughput

0.571

High

717244

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

724733

CDC42
Cell division control protein 42 homolog

2

0

High-throughput

0.547

High

724742

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

0

High-throughput

0.547

High

724754

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

180721

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

724729

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

3

High-throughput

0.536

High

724731

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.536

High

724773

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

724823

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

724723

RHG25
Rho GTPase-activating protein 25

2

4

High-throughput

0.521

High

724716

HSP74
Heat shock 70 kDa protein 4

1

5

High-throughput

0.515

High

225540

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.515

High

724798

PELO
Protein pelota homolog

1

1

High-throughput

0.515

High

135515

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

361136

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

185458

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

724738

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

391689

MT2
Metallothionein-2

1

0

High-throughput

0.493

High

724740

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.493

High

724771

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.493

High

724774

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.493

High

724783

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.493

High

724794

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

0

High-throughput

0.493

High

724796

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.489

High

169454

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

156997

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

411439

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

724715

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

724717

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

724730

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.479

High

724734

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

724736

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

724749

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

724752

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

724753

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

724759

RHG21
Rho GTPase-activating protein 21

1

4

High-throughput

0.479

High

724761

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

724770

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

724772

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

1

High-throughput

0.479

High

724777

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

724795

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

1

High-throughput

0.479

High

724800

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

724806

MT21D
Protein N-lysine methyltransferase METTL21D

1

1

High-throughput

0.479

High

724808

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

724814

RHG23
Rho GTPase-activating protein 23

1

3

High-throughput

0.479

High

724816

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

724818

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

724821

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

724732

RBM11
Splicing regulator RBM11

1

3

High-throughput

0.470

High

724780

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.470

High

134573

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

293269

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

315180

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

316355

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.458

High

319441

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349823

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

408690

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

486997

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

522050

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.458

High

536590

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

659972

COF1
Cofilin-1

1

0

High-throughput

0.458

High

666074

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

719193

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

724721

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

724722

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

724724

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

724725

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

724728

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

724737

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

724743

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

724744

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

724745

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

724751

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

724762

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

724767

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

724775

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

724778

DOCK3
Dedicator of cytokinesis protein 3

1

0

High-throughput

0.458

High

724781

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

724785

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

724789

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

724790

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

724793

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

724803

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

724809

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

724810

ANLN
Anillin

1

0

High-throughput

0.458

High

724811

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

724812

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

724815

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

724819

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

724822

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

724804

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

225256

HTSF1
17S U2 SnRNP complex component HTATSF1

1

2

High-throughput

0.437

High

371274

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

606301

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

703910

DUS1
Dual specificity protein phosphatase 1

1

1

High-throughput

0.437

High

724720

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

724735

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

724755

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

724768

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

724776

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

724779

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.437

High

724784

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.437

High

724805

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

397905

ANGI
Angiogenin

1

0

High-throughput

0.426

High

404695

PRIO
Major prion protein

1

0

High-throughput

0.426

High

529181

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

613303

VINC
Vinculin

1

0

High-throughput

0.426

High

724758

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

724727

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

105426

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

259508

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.305

High

724765

PKHG7
Pleckstrin homology domain-containing family G member 7

2

0

High-throughput

0.298

High

724797

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

249098

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

133447

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

484398

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

723978

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

345156

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.268

Low

467385

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.268

Low

590386

GATA1
Erythroid transcription factor

1

0

High-throughput

0.268

Low

724746

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.268

Low

724763

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

724764

CC141
Coiled-coil domain-containing protein 141

1

0

High-throughput

0.268

Low

724791

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.268

Low

724817

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.268

Low

60216

TM213
Transmembrane protein 213

1

0

High-throughput

0.251

Low

257356

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

377423

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

588005

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

642652

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

694716

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

698422

CALX
Calnexin

1

0

High-throughput

0.249

Low

724718

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

724719

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

724726

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

724739

H31
Histone H3.1

1

0

High-throughput

0.249

Low

724750

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

724760

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

724766

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

724769

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

724787

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.249

Low

724788

RAB8B
Ras-related protein Rab-8B

1

0

High-throughput

0.249

Low

724792

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.249

Low

724799

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

724801

ARP6
Actin-related protein 6

1

0

High-throughput

0.249

Low

724802

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

724807

MAGF1
Melanoma-associated antigen F1

1

0

Small-scale

0.249

Low

724820

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

940

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

87344

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

724782

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025