Protein: METK2
S-adenosylmethionine synthase 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2)

Gene: METK2, SAM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: P19358

Gene Ontology (top 5):
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006555 - methionine metabolic process
GO:0006556 - S-adenosylmethionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

531237

METK1
S-adenosylmethionine synthase 1

6

16

Small-scale

0.944

High

621337

METK2
S-adenosylmethionine synthase 2

2

15

High-throughput

0.762

High

621387

ACS2
Acetyl-coenzyme A synthetase 2

2

2

Small-scale

0.611

High

364920

KPYK1
Pyruvate kinase 1

2

2

Small-scale

0.584

High

621382

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

621369

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.575

High

621370

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.575

High

621380

LCB2
Serine palmitoyltransferase 2

2

1

High-throughput

0.567

High

621374

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

621383

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.546

High

523007

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.536

High

621363

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.536

High

621397

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

621408

IMB1
Importin subunit beta-1

1

1

High-throughput

0.536

High

621401

KA120
Importin beta-like protein KAP120

1

0

High-throughput

0.518

High

621364

YLF2
Obg-like ATPase homolog

1

2

High-throughput

0.515

High

416796

DNLI1
DNA ligase 1

1

1

High-throughput

0.500

High

449313

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.500

High

560646

KIN2
Serine/threonine-protein kinase KIN2

1

1

High-throughput

0.500

High

574632

KSS1
Mitogen-activated protein kinase KSS1

1

5

High-throughput

0.500

High

621354

RAD24
Checkpoint protein RAD24

1

3

High-throughput

0.500

High

621360

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.500

High

621375

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.500

High

621396

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.500

High

621404

CTK1
CTD kinase subunit alpha

1

2

High-throughput

0.500

High

621405

MUS81
Crossover junction endonuclease MUS81

1

1

High-throughput

0.500

High

621338

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.479

High

621416

YP150
Putative serine/threonine-protein kinase YPL150W

1

0

High-throughput

0.479

High

149570

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

368585

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

439234

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.479

High

454860

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

464547

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.479

High

572510

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

621340

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

621341

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

621345

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

621348

URK1
Uridine kinase

1

2

High-throughput

0.479

High

621350

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

621351

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.479

High

621355

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

621359

ARL1
ADP-ribosylation factor-like protein 1

1

2

High-throughput

0.479

High

621362

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

621367

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

621371

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

621372

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

621390

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.479

High

621394

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.479

High

621398

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

621402

FDC1
Ferulic acid decarboxylase 1

1

1

High-throughput

0.479

High

621403

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

621417

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

621418

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.479

High

621419

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

367886

ENO2
Enolase 2

1

0

High-throughput

0.458

High

621412

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

621399

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.457

High

444826

SIR3
Regulatory protein SIR3

1

1

High-throughput

0.457

High

459012

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

621344

PWP2
Periodic tryptophan protein 2

1

2

High-throughput

0.457

High

621346

CDC20
APC/C activator protein CDC20

1

3

High-throughput

0.457

High

621347

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

621368

TEM1
Protein TEM1

1

2

High-throughput

0.457

High

621391

ELOA1
Elongin-A

1

1

High-throughput

0.457

High

621407

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

621411

RBX1
RING-box protein HRT1

1

1

High-throughput

0.457

High

621420

HSH49
Protein HSH49

1

1

High-throughput

0.457

High

392197

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

481473

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

525880

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

543763

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

578813

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.445

High

621352

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

621353

HSP79
Heat shock protein homolog SSE2

1

11

High-throughput

0.445

High

621366

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

621373

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

621400

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

558572

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

564640

STE12
Protein STE12

1

1

Small-scale

0.437

High

621342

GID7
GID complex subunit 7

1

2

High-throughput

0.437

High

621349

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

621358

NOT4
General negative regulator of transcription subunit 4

1

1

Small-scale

0.437

High

621361

ARPC1
Actin-related protein 2/3 complex subunit 1

1

2

High-throughput

0.437

High

621365

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

621377

ULP2
Ubiquitin-like-specific protease 2

1

1

Small-scale

0.437

High

621379

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

621381

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.437

High

621384

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

621385

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

621388

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

621389

CAF40
Protein CAF40

1

1

Small-scale

0.437

High

621393

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

621413

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

621414

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.279

Low

621421

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

449277

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

561702

HAP3
Transcriptional activator HAP3

1

0

High-throughput

0.261

Low

621339

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

621392

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.261

Low

621395

YE066
Putative uncharacterized protein YER066C-A

1

0

High-throughput

0.261

Low

621409

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.261

Low

621343

PER1
Protein PER1

1

0

High-throughput

0.249

Low

621356

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

621357

TOM6
Mitochondrial import receptor subunit TOM6

1

0

High-throughput

0.249

Low

621376

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

621378

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

621386

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

621406

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

621410

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

621415

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

613834

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025